Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.
Publication
, Journal Article
Datto, M; Wang, X-F
Published in: Cell
April 8, 2005
Effects of the cytokine TGF-beta can be dampened by E3 ubiquitin ligases that target specific Smads, the TGF-beta signal transducers, for proteolytic destruction. Two papers in this issue of Cell highlight the importance of this mechanism in regulating the in vivo effects of TGF-beta. The first paper identifies and characterizes a novel Smad4 ubiquitin ligase, and the second paper redefines the role of a previously identified Smad1 ubiquitin ligase, Smurf-1 (Dupont et al., 2005; Yamashita et al., 2005).
Duke Scholars
Published In
Cell
DOI
ISSN
0092-8674
Publication Date
April 8, 2005
Volume
121
Issue
1
Start / End Page
2 / 4
Location
United States
Related Subject Headings
- Xenopus
- Ubiquitin-Protein Ligases
- Transforming Growth Factor beta
- Trans-Activators
- Smad4 Protein
- Signal Transduction
- Receptors, Growth Factor
- Protein Denaturation
- Osteoblasts
- Mice
Citation
APA
Chicago
ICMJE
MLA
NLM
Datto, M., & Wang, X.-F. (2005). Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. Cell, 121(1), 2–4. https://doi.org/10.1016/j.cell.2005.03.017
Datto, M., and X. -. F. Wang. “Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.” Cell 121, no. 1 (April 8, 2005): 2–4. https://doi.org/10.1016/j.cell.2005.03.017.
Datto M, Wang X-F. Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. Cell. 2005 Apr 8;121(1):2–4.
Datto, M., and X. .. F. Wang. “Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.” Cell, vol. 121, no. 1, Apr. 2005, pp. 2–4. Pubmed, doi:10.1016/j.cell.2005.03.017.
Datto M, Wang X-F. Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling. Cell. 2005 Apr 8;121(1):2–4.
Published In
Cell
DOI
ISSN
0092-8674
Publication Date
April 8, 2005
Volume
121
Issue
1
Start / End Page
2 / 4
Location
United States
Related Subject Headings
- Xenopus
- Ubiquitin-Protein Ligases
- Transforming Growth Factor beta
- Trans-Activators
- Smad4 Protein
- Signal Transduction
- Receptors, Growth Factor
- Protein Denaturation
- Osteoblasts
- Mice