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Emergence of the keratinocyte growth factor multigene family during the great ape radiation.

Publication ,  Journal Article
Kelley, MJ; Pech, M; Seuanez, HN; Rubin, JS; O'Brien, SJ; Aaronson, SA
Published in: Proc Natl Acad Sci U S A
October 1, 1992

The structural gene for human keratinocyte growth factor (KGF), a member of the fibroblast growth factor family, consists of three coding exons and two introns typical of other fibroblast growth factor loci. A portion of the KGF gene, located on chromosome 15, is amplified to approximately 16 copies in the human genome, and these highly related copies (which consist of exon 2, exon 3, the intron between them, and a 3' noncoding segment of the KGF transcript) are dispersed to multiple human chromosomes. The KGF-like sequences are transcriptionally active, differentially regulated in various tissues, and composed of three distinct classes of coding sequences that are 5% divergent from each other and from the authentic KGF sequence. Multiple copies of KGF-like genes were also discovered in the genomic DNAs of chimpanzee and gorilla but were not found in lesser apes (gibbon), Old World monkeys (African green monkey and macaques), mice, or chickens. The pattern of evolutionary occurrence suggests that a primordial KGF gene was amplified and chromosomally dispersed subsequent to the divergence of orangutan from African apes but before the trichotomous divergence of human, chimpanzee, and gorilla 5-8 million years ago. The appearance of a transcriptionally active and chromosomally dispersed multigene KGF family may have implications in the evolution of the great apes and humans.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

October 1, 1992

Volume

89

Issue

19

Start / End Page

9287 / 9291

Location

United States

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Restriction Mapping
  • Primates
  • Pongo pygmaeus
  • Polymerase Chain Reaction
  • Pan troglodytes
  • Oligodeoxyribonucleotides
  • Multigene Family
  • Molecular Sequence Data
  • Macaca mulatta
 

Citation

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Kelley, M. J., Pech, M., Seuanez, H. N., Rubin, J. S., O’Brien, S. J., & Aaronson, S. A. (1992). Emergence of the keratinocyte growth factor multigene family during the great ape radiation. Proc Natl Acad Sci U S A, 89(19), 9287–9291. https://doi.org/10.1073/pnas.89.19.9287
Kelley, M. J., M. Pech, H. N. Seuanez, J. S. Rubin, S. J. O’Brien, and S. A. Aaronson. “Emergence of the keratinocyte growth factor multigene family during the great ape radiation.Proc Natl Acad Sci U S A 89, no. 19 (October 1, 1992): 9287–91. https://doi.org/10.1073/pnas.89.19.9287.
Kelley MJ, Pech M, Seuanez HN, Rubin JS, O’Brien SJ, Aaronson SA. Emergence of the keratinocyte growth factor multigene family during the great ape radiation. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9287–91.
Kelley, M. J., et al. “Emergence of the keratinocyte growth factor multigene family during the great ape radiation.Proc Natl Acad Sci U S A, vol. 89, no. 19, Oct. 1992, pp. 9287–91. Pubmed, doi:10.1073/pnas.89.19.9287.
Kelley MJ, Pech M, Seuanez HN, Rubin JS, O’Brien SJ, Aaronson SA. Emergence of the keratinocyte growth factor multigene family during the great ape radiation. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9287–9291.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

October 1, 1992

Volume

89

Issue

19

Start / End Page

9287 / 9291

Location

United States

Related Subject Headings

  • Sequence Homology, Nucleic Acid
  • Restriction Mapping
  • Primates
  • Pongo pygmaeus
  • Polymerase Chain Reaction
  • Pan troglodytes
  • Oligodeoxyribonucleotides
  • Multigene Family
  • Molecular Sequence Data
  • Macaca mulatta