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A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.

Publication ,  Journal Article
Tao, X; West, AE; Chen, WG; Corfas, G; Greenberg, ME
Published in: Neuron
January 31, 2002

Transcription of the brain-derived neurotrophic factor (BDNF) gene is regulated in a calcium- and neuron-selective manner; however, the mechanisms that underlie this selectivity are not known. We have characterized a new calcium-response element, CaRE1, that is required for activity-dependent transcription of BDNF exon III and have cloned a transcription factor, CaRF, that activates transcription from BDNF promoter III in a CaRE1-dependent manner. The transcriptional activity of CaRF is regulated in a calcium- and neuron-selective manner, suggesting that CaRF may confer selectivity upon the activity-dependent induction of BDNF exon III expression.

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Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

January 31, 2002

Volume

33

Issue

3

Start / End Page

383 / 395

Location

United States

Related Subject Headings

  • Two-Hybrid System Techniques
  • Transcription Factors
  • Tissue Distribution
  • Response Elements
  • Regulatory Sequences, Nucleic Acid
  • Rats, Long-Evans
  • Rats
  • Phosphodiesterase Inhibitors
  • Nuclear Proteins
  • Neurons
 

Citation

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Tao, X., West, A. E., Chen, W. G., Corfas, G., & Greenberg, M. E. (2002). A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron, 33(3), 383–395. https://doi.org/10.1016/s0896-6273(01)00561-x
Tao, Xu, Anne E. West, Wen G. Chen, Gabriel Corfas, and Michael E. Greenberg. “A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.Neuron 33, no. 3 (January 31, 2002): 383–95. https://doi.org/10.1016/s0896-6273(01)00561-x.
Tao X, West AE, Chen WG, Corfas G, Greenberg ME. A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron. 2002 Jan 31;33(3):383–95.
Tao, Xu, et al. “A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.Neuron, vol. 33, no. 3, Jan. 2002, pp. 383–95. Pubmed, doi:10.1016/s0896-6273(01)00561-x.
Tao X, West AE, Chen WG, Corfas G, Greenberg ME. A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. Neuron. 2002 Jan 31;33(3):383–395.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

January 31, 2002

Volume

33

Issue

3

Start / End Page

383 / 395

Location

United States

Related Subject Headings

  • Two-Hybrid System Techniques
  • Transcription Factors
  • Tissue Distribution
  • Response Elements
  • Regulatory Sequences, Nucleic Acid
  • Rats, Long-Evans
  • Rats
  • Phosphodiesterase Inhibitors
  • Nuclear Proteins
  • Neurons