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Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788.

Publication ,  Journal Article
Morgan, MM; Levin, ED; Liebeskind, JC
Published in: Brain Res
July 14, 1987

Three experiments were carried out in rats to evaluate the analgesic effects of the benzodiazepine antagonist, Ro 15-1788. Expt. 1 demonstrated a diazepam reversible analgesic effect of Ro 15-1788 using the tail-flick test. Expt. 2 analyzed the effects of Ro 15-1788 in the hot-plate test at various doses. Low doses of Ro 15-1788 proved analgesia 20 min after drug injection, whereas high doses had no analgesic effect on the 20 min test, but were effective on the 50 min test. Expt. 3 demonstrated that the opiate antagonist, naloxone, had no effect on analgesia produced by Ro 15-1788 in the hot-plate test. The analgesic effects of Ro 15-1788 may be attributable to its reported anxiogenic properties.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

July 14, 1987

Volume

415

Issue

2

Start / End Page

367 / 370

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Naloxone
  • Male
  • Flumazenil
  • Diazepam
  • Animals
  • Analgesics
  • 1702 Cognitive Sciences
 

Citation

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Morgan, M. M., Levin, E. D., & Liebeskind, J. C. (1987). Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788. Brain Res, 415(2), 367–370. https://doi.org/10.1016/0006-8993(87)90222-8
Morgan, M. M., E. D. Levin, and J. C. Liebeskind. “Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788.Brain Res 415, no. 2 (July 14, 1987): 367–70. https://doi.org/10.1016/0006-8993(87)90222-8.
Morgan MM, Levin ED, Liebeskind JC. Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788. Brain Res. 1987 Jul 14;415(2):367–70.
Morgan, M. M., et al. “Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788.Brain Res, vol. 415, no. 2, July 1987, pp. 367–70. Pubmed, doi:10.1016/0006-8993(87)90222-8.
Morgan MM, Levin ED, Liebeskind JC. Characterization of the analgesic effects of the benzodiazepine antagonist, Ro 15-1788. Brain Res. 1987 Jul 14;415(2):367–370.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

July 14, 1987

Volume

415

Issue

2

Start / End Page

367 / 370

Location

Netherlands

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Naloxone
  • Male
  • Flumazenil
  • Diazepam
  • Animals
  • Analgesics
  • 1702 Cognitive Sciences