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Suppressive effects of halothane on reactive synaptogenesis in the dentate gyrus of rats.

Publication ,  Journal Article
Uemura, E; Levin, ED; DeLuna, R; Bowman, RE
Published in: Brain Res
September 4, 1989

Reactive synaptogenesis was studied in the dentate gyrus of rats exposed to 100 parts per million of halothane for 15 days starting on the day after unilateral entorhinal lesioning. Halothane exposure markedly affected the replacement of synapses. Only 17% of the lost synapses were restored by day 15 postlesion in rats exposed to halothane, while 73% of the lost synapses were recovered in rats not exposed to halothane. However, this suppression in initial reactive synaptogenesis did not result in permanent deficits in synaptic population. After halothane exposure was stopped, reactive synaptogenesis resumed, and by day 30 after the lesion, the synaptic population of the experimental group caught up to the control level. This suppressive action of halothane suggests its utility as a research tool for delaying synaptogenesis during selected developmental epochs to study the relationship between synaptic and behavioral recovery.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

September 4, 1989

Volume

496

Issue

1-2

Start / End Page

317 / 320

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Synapses
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Nerve Regeneration
  • Male
  • Hippocampus
  • Halothane
  • Axons
 

Citation

APA
Chicago
ICMJE
MLA
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Uemura, E., Levin, E. D., DeLuna, R., & Bowman, R. E. (1989). Suppressive effects of halothane on reactive synaptogenesis in the dentate gyrus of rats. Brain Res, 496(1–2), 317–320. https://doi.org/10.1016/0006-8993(89)91080-9
Uemura, E., E. D. Levin, R. DeLuna, and R. E. Bowman. “Suppressive effects of halothane on reactive synaptogenesis in the dentate gyrus of rats.Brain Res 496, no. 1–2 (September 4, 1989): 317–20. https://doi.org/10.1016/0006-8993(89)91080-9.
Uemura E, Levin ED, DeLuna R, Bowman RE. Suppressive effects of halothane on reactive synaptogenesis in the dentate gyrus of rats. Brain Res. 1989 Sep 4;496(1–2):317–20.
Uemura, E., et al. “Suppressive effects of halothane on reactive synaptogenesis in the dentate gyrus of rats.Brain Res, vol. 496, no. 1–2, Sept. 1989, pp. 317–20. Pubmed, doi:10.1016/0006-8993(89)91080-9.
Uemura E, Levin ED, DeLuna R, Bowman RE. Suppressive effects of halothane on reactive synaptogenesis in the dentate gyrus of rats. Brain Res. 1989 Sep 4;496(1–2):317–320.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

September 4, 1989

Volume

496

Issue

1-2

Start / End Page

317 / 320

Location

Netherlands

Related Subject Headings

  • Time Factors
  • Synapses
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • Nerve Regeneration
  • Male
  • Hippocampus
  • Halothane
  • Axons