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Persisting behavioral consequences of prenatal domoic acid exposure in rats.

Publication ,  Journal Article
Levin, ED; Pizarro, K; Pang, WG; Harrison, J; Ramsdell, JS
Published in: Neurotoxicol Teratol
2005

To investigate the behavioral effects of prenatal exposure to the marine toxin domoic acid, pregnant female rats were injected subcutaneously with 0, 0.3, 0.6, or 1.2 mg/kg of domoic acid on gestational day 13. The offspring were then run through a behavioral testing battery to determine the developmental effects of the toxin on spontaneous alternation in the T-maze, on locomotor activity in the Figure-8 maze, and on working memory in the 8-arm radial maze. In the T-maze, no significant domoic acid induced differences were seen on spontaneous alternation, but there were significant domoic acid effects on latency. Prenatal domoic acid exposure caused a dose-related increase in response latency in the second spontaneous alternation test. There was also a significant domoic acid effect seen in the 1-h long Figure-8 maze test. Locomotor activity measured in the Figure-8 maze detected a persisting effect of the 1.2 mg/kg domoic acid dose, which significantly increased the rate of habituation over the activity test session. This was characterized by higher initial activity followed by greater decline in activity. In the radial-arm maze the control vehicle treated rats showed the normal sex-related difference in spatial learning and memory with males outperforming females. Developmental domoic acid exposure decreased this effect such that the normal sex difference in spatial memory was not seen with the 1.2 mg/kg domoic acid dose. The rats of both sexes with a history of prenatal domoic acid exposure showed increased susceptibility to the amnestic effects of the muscarinic acetylcholine scopolamine, suggesting that they had less functional reserve with which to solve the radial-arm maze memory task. This study demonstrates persisting neurobehavioral effects of acute prenatal exposure to domoic acid at doses that do not cause overt clinical signs of toxicity.

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Published In

Neurotoxicol Teratol

DOI

ISSN

0892-0362

Publication Date

2005

Volume

27

Issue

5

Start / End Page

719 / 725

Location

United States

Related Subject Headings

  • Toxicology
  • Sex Characteristics
  • Scopolamine
  • Rats, Sprague-Dawley
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Neurotoxins
  • Muscarinic Antagonists
  • Motor Activity
 

Citation

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Levin, E. D., Pizarro, K., Pang, W. G., Harrison, J., & Ramsdell, J. S. (2005). Persisting behavioral consequences of prenatal domoic acid exposure in rats. Neurotoxicol Teratol, 27(5), 719–725. https://doi.org/10.1016/j.ntt.2005.06.017
Levin, Edward D., Kristen Pizarro, Wyki Gina Pang, Jerry Harrison, and John S. Ramsdell. “Persisting behavioral consequences of prenatal domoic acid exposure in rats.Neurotoxicol Teratol 27, no. 5 (2005): 719–25. https://doi.org/10.1016/j.ntt.2005.06.017.
Levin ED, Pizarro K, Pang WG, Harrison J, Ramsdell JS. Persisting behavioral consequences of prenatal domoic acid exposure in rats. Neurotoxicol Teratol. 2005;27(5):719–25.
Levin, Edward D., et al. “Persisting behavioral consequences of prenatal domoic acid exposure in rats.Neurotoxicol Teratol, vol. 27, no. 5, 2005, pp. 719–25. Pubmed, doi:10.1016/j.ntt.2005.06.017.
Levin ED, Pizarro K, Pang WG, Harrison J, Ramsdell JS. Persisting behavioral consequences of prenatal domoic acid exposure in rats. Neurotoxicol Teratol. 2005;27(5):719–725.
Journal cover image

Published In

Neurotoxicol Teratol

DOI

ISSN

0892-0362

Publication Date

2005

Volume

27

Issue

5

Start / End Page

719 / 725

Location

United States

Related Subject Headings

  • Toxicology
  • Sex Characteristics
  • Scopolamine
  • Rats, Sprague-Dawley
  • Rats
  • Prenatal Exposure Delayed Effects
  • Pregnancy
  • Neurotoxins
  • Muscarinic Antagonists
  • Motor Activity