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Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze.

Publication ,  Journal Article
Levin, ED
Published in: Pharmacol Biochem Behav
December 1995

Antagonists of nicotinic and muscarinic acetylcholinergic (ACh) receptors have significant interactions with dopaminergic (DA) ligands with regard to radial-arm maze choice accuracy. The current studies examined the interactions of agonists of nicotinic and muscarinic ACh receptors with the DA agonist pergolide. Pergolide given in a range from 0.03-1.0 mg/kg had no detectable effect on radial-arm maze choice accuracy when given alone. With this dose range there was a linear increase in response latency. Pergolide had significant interactive effects with the nicotinic and muscarinic agonists nicotine and pilocarpine. Given together with nicotine, pergolide produced a significantly elevated linear increase in accuracy relative to when it was given alone. With pilocarpine, pergolide had an inverted U-shaped effect improving choice accuracy at low to moderate doses of 0.03 and 0.1 mg/kg. These results support previous findings of DA-ACh interactions with regard to radial-arm maze choice accuracy. Combined DA-ACh treatment may be a useful treatment of cognitive dysfunction.

Duke Scholars

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

December 1995

Volume

52

Issue

4

Start / End Page

837 / 840

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pilocarpine
  • Pergolide
  • Nicotine
  • Neurology & Neurosurgery
  • Maze Learning
  • Female
  • Drug Interactions
  • Dose-Response Relationship, Drug
 

Citation

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Levin, E. D. (1995). Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze. Pharmacol Biochem Behav, 52(4), 837–840. https://doi.org/10.1016/0091-3057(95)00165-s
Levin, E. D. “Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze.Pharmacol Biochem Behav 52, no. 4 (December 1995): 837–40. https://doi.org/10.1016/0091-3057(95)00165-s.
Levin ED. Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze. Pharmacol Biochem Behav. 1995 Dec;52(4):837–40.
Levin, E. D. “Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze.Pharmacol Biochem Behav, vol. 52, no. 4, Dec. 1995, pp. 837–40. Pubmed, doi:10.1016/0091-3057(95)00165-s.
Levin ED. Pergolide interactions with nicotine and pilocarpine in rats on the radial-arm maze. Pharmacol Biochem Behav. 1995 Dec;52(4):837–840.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

December 1995

Volume

52

Issue

4

Start / End Page

837 / 840

Location

United States

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pilocarpine
  • Pergolide
  • Nicotine
  • Neurology & Neurosurgery
  • Maze Learning
  • Female
  • Drug Interactions
  • Dose-Response Relationship, Drug