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Neuroleptic-induced oral movements in rats: methodological issues.

Publication ,  Journal Article
Levy, AD; See, RE; Levin, ED; Ellison, GD
Published in: Life Sci
September 21, 1987

In three separate experiments groups of rats were chronically administered neuroleptics in a variety of ways (chronic injections, subcutaneous implants, and decanoate injections) and examined for oral movements (OMs) in two different tests: in an open cage using a human observer, or in a plexiglas tube enclosure, where OMs were monitored both by a human observer and computerized video analysis system. These two testing methods showed different effects of neuroleptic administration. In the open cage, OMs tended to be enhanced during chronic neuroleptic exposure and to rapidly subside upon drug withdrawal. The enhanced OMs were especially present just after drug injections, when activity levels were low. In the observation tube environment, however, OMs tended to be low soon after drug treatments, and elevated upon withdrawal. Thus, the type of behavioral test used determines how neuroleptic-induced increases in oral activity should be interpreted.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

September 21, 1987

Volume

41

Issue

12

Start / End Page

1499 / 1506

Location

Netherlands

Related Subject Headings

  • Rats
  • Pharmacology & Pharmacy
  • Movement
  • Mouth
  • Methods
  • Haloperidol
  • Fluphenazine
  • Female
  • Dyskinesia, Drug-Induced
  • Antipsychotic Agents
 

Citation

APA
Chicago
ICMJE
MLA
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Levy, A. D., See, R. E., Levin, E. D., & Ellison, G. D. (1987). Neuroleptic-induced oral movements in rats: methodological issues. Life Sci, 41(12), 1499–1506. https://doi.org/10.1016/0024-3205(87)90715-6
Levy, A. D., R. E. See, E. D. Levin, and G. D. Ellison. “Neuroleptic-induced oral movements in rats: methodological issues.Life Sci 41, no. 12 (September 21, 1987): 1499–1506. https://doi.org/10.1016/0024-3205(87)90715-6.
Levy AD, See RE, Levin ED, Ellison GD. Neuroleptic-induced oral movements in rats: methodological issues. Life Sci. 1987 Sep 21;41(12):1499–506.
Levy, A. D., et al. “Neuroleptic-induced oral movements in rats: methodological issues.Life Sci, vol. 41, no. 12, Sept. 1987, pp. 1499–506. Pubmed, doi:10.1016/0024-3205(87)90715-6.
Levy AD, See RE, Levin ED, Ellison GD. Neuroleptic-induced oral movements in rats: methodological issues. Life Sci. 1987 Sep 21;41(12):1499–1506.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

September 21, 1987

Volume

41

Issue

12

Start / End Page

1499 / 1506

Location

Netherlands

Related Subject Headings

  • Rats
  • Pharmacology & Pharmacy
  • Movement
  • Mouth
  • Methods
  • Haloperidol
  • Fluphenazine
  • Female
  • Dyskinesia, Drug-Induced
  • Antipsychotic Agents