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S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity.

Publication ,  Journal Article
Hershfield, MS; Krodich, NM
Published in: Science
November 17, 1978

When adenosine deaminase activity is inhibited, low concentrations of adenosine are toxic to human lymphoblast mutants that are unable to convert adenosine to intracellular nucleotides. In order to identify the mediator of this cytotoxicity, we searched for a cytoplasmic protein capable of binding adenosine with high affinity. Such a protein was identified in extracts of human lymphoblasts and placenta as the enzyme S-adenosylhomocysteine hydrolase.

Duke Scholars

Published In

Science

DOI

ISSN

0036-8075

Publication Date

November 17, 1978

Volume

202

Issue

4369

Start / End Page

757 / 760

Location

United States

Related Subject Headings

  • S-Adenosylhomocysteine
  • Pregnancy
  • Placenta
  • Nucleoside Deaminases
  • Lymphocytes
  • Kinetics
  • Hydrolases
  • Humans
  • General Science & Technology
  • Female
 

Citation

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MLA
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Hershfield, M. S., & Krodich, N. M. (1978). S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity. Science, 202(4369), 757–760. https://doi.org/10.1126/science.715439
Hershfield, M. S., and N. M. Krodich. “S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity.Science 202, no. 4369 (November 17, 1978): 757–60. https://doi.org/10.1126/science.715439.
Hershfield MS, Krodich NM. S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity. Science. 1978 Nov 17;202(4369):757–60.
Hershfield, M. S., and N. M. Krodich. “S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity.Science, vol. 202, no. 4369, Nov. 1978, pp. 757–60. Pubmed, doi:10.1126/science.715439.
Hershfield MS, Krodich NM. S-adenosylhomocysteine hydrolase is an adenosine-binding protein: a target for adenosine toxicity. Science. 1978 Nov 17;202(4369):757–760.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

November 17, 1978

Volume

202

Issue

4369

Start / End Page

757 / 760

Location

United States

Related Subject Headings

  • S-Adenosylhomocysteine
  • Pregnancy
  • Placenta
  • Nucleoside Deaminases
  • Lymphocytes
  • Kinetics
  • Hydrolases
  • Humans
  • General Science & Technology
  • Female