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The Lyapunov exponent of the EEG after administration of topiramate.

Publication ,  Journal Article
Li, JC; Wang, WW; Wang, YH; Wu, X
Published in: Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS)
July 2005

The objective of our study was to investigate the effect of topiramate (TPM) on the Lyapunov exponent of EEG by means of quantitative pharmacoelectroencephalography (QPEEG) and nonlinear analysis methods. One dose of TPM was administrated to epileptics and healthy adults. EEG samples were obtained prior to and at regular intervals (at 0.5, 1, 2, 4, 6, 8, 12, 24 hours) within the 24 hours following the administration of TPM. EEG activity was processed with nonlinear analysis methods. The Lyapunov exponent of the scalp areas was calculated through 60 s epochs without artifacts after each recording. The statistical difference between baseline predrug assessment and each postdrug control was calculated by computing the paired t test. Results showed that the Lyapunov exponent increased first, then decreased, then increased finally. We conclude that TPM can change the complexity of EEG.

Duke Scholars

Published In

Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS)

ISSN

1550-0594

Publication Date

July 2005

Volume

36

Issue

3

Start / End Page

202 / 206

Location

united states

Related Subject Headings

  • Neurology & Neurosurgery
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Li, J. C., Wang, W. W., Wang, Y. H., & Wu, X. (2005). The Lyapunov exponent of the EEG after administration of topiramate. Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS), 36(3), 202–206.
Li, J. C., W. W. Wang, Y. H. Wang, and X. Wu. “The Lyapunov exponent of the EEG after administration of topiramate.Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS) 36, no. 3 (July 2005): 202–6.
Li JC, Wang WW, Wang YH, Wu X. The Lyapunov exponent of the EEG after administration of topiramate. Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS). 2005 Jul;36(3):202–6.
Li, J. C., et al. “The Lyapunov exponent of the EEG after administration of topiramate.Clinical EEG and Neuroscience : Official Journal of the EEG and Clinical Neuroscience Society (ENCS), vol. 36, no. 3, July 2005, pp. 202–06.
Li JC, Wang WW, Wang YH, Wu X. The Lyapunov exponent of the EEG after administration of topiramate. Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS). 2005 Jul;36(3):202–206.
Journal cover image

Published In

Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS)

ISSN

1550-0594

Publication Date

July 2005

Volume

36

Issue

3

Start / End Page

202 / 206

Location

united states

Related Subject Headings

  • Neurology & Neurosurgery
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences