Deficient repair of DNA lesions in Alzheimer's disease fibroblasts.
Publication
, Journal Article
Li, JC; Kaminskas, E
Published in: Biochemical and biophysical research communications
June 1985
DNA strand breaks, resulting from treatment with N-methyl-N'-nitro-N-nitrosoguanidine, were repaired more slowly in four strains of familial Alzheimer's disease fibroblasts than in five strains of fibroblasts from age-matched normals. These results were not due to differences between the two cell types in in vitro ages, in the initial DNA damage or in drug-induced cell lysis. Bleomycin-induced DNA double-strand breaks were repaired equally efficiently by both types of cells. Alzheimer's disease cells may have a DNA repair defect, which may be involved in the pathogenesis of this disease.
Duke Scholars
Published In
Biochemical and biophysical research communications
ISSN
0006-291X
Publication Date
June 1985
Volume
129
Issue
3
Start / End Page
733 / 738
Location
united states
Related Subject Headings
- Biochemistry & Molecular Biology
- 1101 Medical Biochemistry and Metabolomics
- 0601 Biochemistry and Cell Biology
- 0304 Medicinal and Biomolecular Chemistry
Citation
APA
Chicago
ICMJE
MLA
NLM
Li, J. C., & Kaminskas, E. (1985). Deficient repair of DNA lesions in Alzheimer's disease fibroblasts. Biochemical and Biophysical Research Communications, 129(3), 733–738.
Li, J. C., and E. Kaminskas. “Deficient repair of DNA lesions in Alzheimer's disease fibroblasts.” Biochemical and Biophysical Research Communications 129, no. 3 (June 1985): 733–38.
Li JC, Kaminskas E. Deficient repair of DNA lesions in Alzheimer's disease fibroblasts. Biochemical and biophysical research communications. 1985 Jun;129(3):733–8.
Li, J. C., and E. Kaminskas. “Deficient repair of DNA lesions in Alzheimer's disease fibroblasts.” Biochemical and Biophysical Research Communications, vol. 129, no. 3, June 1985, pp. 733–38.
Li JC, Kaminskas E. Deficient repair of DNA lesions in Alzheimer's disease fibroblasts. Biochemical and biophysical research communications. 1985 Jun;129(3):733–738.
Published In
Biochemical and biophysical research communications
ISSN
0006-291X
Publication Date
June 1985
Volume
129
Issue
3
Start / End Page
733 / 738
Location
united states
Related Subject Headings
- Biochemistry & Molecular Biology
- 1101 Medical Biochemistry and Metabolomics
- 0601 Biochemistry and Cell Biology
- 0304 Medicinal and Biomolecular Chemistry