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[A mouse model of severe acute pancreatitis induced by caerulein plus lipopolysaccharide]

Publication ,  Journal Article
Jin, C; Li, JC
Published in: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
August 2002

OBJECTIVE: To set up a convenient nontraumatic mouse model of severe acute pancreatitis(SAP). METHODS: Mice received intraperitoneal injections with caerulein and lipopolysaccharide (LPS). Serum amylase and pancreatic moisture content were measured during experiment. The histo pathological changes of pancreas and relevant organs were observed under light microscope. RESULTS: Serum amylase and pancreatic moisture content increased and pancreatic interstitial edema, inflammatory cellular infiltration, parenchymal necrosis as well as parenchymal hemorrhages were happened in the caerulein plus LPS group, and the lesions of other organs including stomach, ileum, spleen, and lung were seen as well. In the careulein group, there was only pancreatic interstitial edema with no parenchmal necrosis or hemorrhage, and the rest organs were normal. CONCLUSIONS: The SAP mouse model induced by caerulein plus LPS has the same pathological characteristics of human SAP, which can be used for human SAP studies.

Duke Scholars

Published In

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

ISSN

1000-503X

Publication Date

August 2002

Volume

24

Issue

4

Start / End Page

393 / 396

Location

china

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

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Jin, C., & Li, J. C. (2002). [A mouse model of severe acute pancreatitis induced by caerulein plus lipopolysaccharide]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, 24(4), 393–396.
Jin, C., and J. C. Li. “[A mouse model of severe acute pancreatitis induced by caerulein plus lipopolysaccharide].” Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae 24, no. 4 (August 2002): 393–96.
Jin C, Li JC. [A mouse model of severe acute pancreatitis induced by caerulein plus lipopolysaccharide]. Zhongguo yi xue ke xue yuan xue bao Acta Academiae Medicinae Sinicae. 2002 Aug;24(4):393–6.
Jin, C., and J. C. Li. “[A mouse model of severe acute pancreatitis induced by caerulein plus lipopolysaccharide].” Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae, vol. 24, no. 4, Aug. 2002, pp. 393–96.
Jin C, Li JC. [A mouse model of severe acute pancreatitis induced by caerulein plus lipopolysaccharide]. Zhongguo yi xue ke xue yuan xue bao Acta Academiae Medicinae Sinicae. 2002 Aug;24(4):393–396.

Published In

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

ISSN

1000-503X

Publication Date

August 2002

Volume

24

Issue

4

Start / End Page

393 / 396

Location

china

Related Subject Headings

  • Oncology & Carcinogenesis
  • 1103 Clinical Sciences