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Sensitive and specific detection of the 4B5 antigen in bronchial lavage specimens from patients with primary bronchogenic carcinoma.

Publication ,  Journal Article
Pence, JC; Deutsch, MA; Kerns, BJ; Huper, G; Jordan, LK; Wolfe, WG; Samuelson, WM; Fulkerson, WJ; Dodge, RK; Plate, CA
Published in: Cancer
September 1, 1992

The monoclonal antibody 4B5 binds to a mucin-like antigen elaborated by respiratory epithelium of patients with non-small cell bronchogenic carcinoma. Several immunoassay formats were used to determine the presence of the antigen in lavage specimens. A qualitative immunodrop binding assay showed immunoreactivity in 37 (64%) of 58 specimens from patients with non-small cell lung cancer. In contrast, only 11 (12%) of 93 specimens from patients with either metastatic carcinoma or benign pulmonary diseases exhibited 4B5 immunoreactivity. A quantitative radioimmunoassay using standardized amounts of mucin exhibited similar sensitivity and specificity. Positive immunoreactivity was associated significantly with tobacco use and the cytopathologic diagnoses of squamous metaplasia, atypia, or dysplasia. Conversely, no significant association was found between 4B5 immunoreactivity and age, gender, race, benign cytologic findings, frankly malignant cytologic findings, or stage of disease. The expression of 4B5 antigen in bronchial secretions from patients with bronchogenic carcinoma deserves additional evaluation as a potential marker of pulmonary carcinogenesis.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

September 1, 1992

Volume

70

Issue

5

Start / End Page

1115 / 1123

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Risk Factors
  • Radioimmunoassay
  • Oncology & Carcinogenesis
  • Mucins
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Lung Diseases
  • Immunoassay
 

Citation

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Pence, J. C., Deutsch, M. A., Kerns, B. J., Huper, G., Jordan, L. K., Wolfe, W. G., … Plate, C. A. (1992). Sensitive and specific detection of the 4B5 antigen in bronchial lavage specimens from patients with primary bronchogenic carcinoma. Cancer, 70(5), 1115–1123. https://doi.org/10.1002/1097-0142(19920901)70:5<1115::aid-cncr2820700516>3.0.co;2-q
Pence, J. C., M. A. Deutsch, B. J. Kerns, G. Huper, L. K. Jordan, W. G. Wolfe, W. M. Samuelson, W. J. Fulkerson, R. K. Dodge, and C. A. Plate. “Sensitive and specific detection of the 4B5 antigen in bronchial lavage specimens from patients with primary bronchogenic carcinoma.Cancer 70, no. 5 (September 1, 1992): 1115–23. https://doi.org/10.1002/1097-0142(19920901)70:5<1115::aid-cncr2820700516>3.0.co;2-q.
Pence JC, Deutsch MA, Kerns BJ, Huper G, Jordan LK, Wolfe WG, et al. Sensitive and specific detection of the 4B5 antigen in bronchial lavage specimens from patients with primary bronchogenic carcinoma. Cancer. 1992 Sep 1;70(5):1115–23.
Pence, J. C., et al. “Sensitive and specific detection of the 4B5 antigen in bronchial lavage specimens from patients with primary bronchogenic carcinoma.Cancer, vol. 70, no. 5, Sept. 1992, pp. 1115–23. Pubmed, doi:10.1002/1097-0142(19920901)70:5<1115::aid-cncr2820700516>3.0.co;2-q.
Pence JC, Deutsch MA, Kerns BJ, Huper G, Jordan LK, Wolfe WG, Samuelson WM, Fulkerson WJ, Dodge RK, Plate CA. Sensitive and specific detection of the 4B5 antigen in bronchial lavage specimens from patients with primary bronchogenic carcinoma. Cancer. 1992 Sep 1;70(5):1115–1123.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

September 1, 1992

Volume

70

Issue

5

Start / End Page

1115 / 1123

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Risk Factors
  • Radioimmunoassay
  • Oncology & Carcinogenesis
  • Mucins
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Lung Diseases
  • Immunoassay