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Chondrosarcoma of bone: analysis of 108 cases and evaluation for predictors of outcome.

Publication ,  Journal Article
Rizzo, M; Ghert, MA; Harrelson, JM; Scully, SP
Published in: Clin Orthop Relat Res
October 2001

Chondrosarcoma is the second most common malignant bone tumor and is relatively unresponsive to chemotherapy and radiation regimens. In addition, the clinical course of chondrosarcoma is difficult to predict. The purpose of this study was to review the authors' experience with chondrosarcoma and ascertain any factors related to prognosis and clinical outcome. The medical records of 108 patients followed up for a minimum of 2 years were retrospectively reviewed. There were 31 low-grade and 77 high-grade chondrosarcomas. One hundred one patients underwent surgical resection. There was a statistically significant association between positive margins and local recurrence, metastasis, and death. Tumor grade was not predictive of outcome. Proliferation indices (MIB-1 expression determination through immunohistochemistry) were quantitated in 39 patients. A significant association was seen between MIB-1 expression and recurrence and death. Thus, objective quantitation of tumor proliferation was more predictive than was histologic grade of outcome in chondrosarcoma. Although histologic grade continues to be the standard grading system for chondrosarcoma, the current study contributes to ongoing research and validation of alternative techniques that may be more reliable in guiding prognosis and treatment of chondrosarcoma.

Duke Scholars

Published In

Clin Orthop Relat Res

ISSN

0009-921X

Publication Date

October 2001

Issue

391

Start / End Page

224 / 233

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Prognosis
  • Orthopedics
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Chondrosarcoma
 

Citation

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Rizzo, M., Ghert, M. A., Harrelson, J. M., & Scully, S. P. (2001). Chondrosarcoma of bone: analysis of 108 cases and evaluation for predictors of outcome. Clin Orthop Relat Res, (391), 224–233.
Rizzo, M., M. A. Ghert, J. M. Harrelson, and S. P. Scully. “Chondrosarcoma of bone: analysis of 108 cases and evaluation for predictors of outcome.Clin Orthop Relat Res, no. 391 (October 2001): 224–33.
Rizzo M, Ghert MA, Harrelson JM, Scully SP. Chondrosarcoma of bone: analysis of 108 cases and evaluation for predictors of outcome. Clin Orthop Relat Res. 2001 Oct;(391):224–33.
Rizzo, M., et al. “Chondrosarcoma of bone: analysis of 108 cases and evaluation for predictors of outcome.Clin Orthop Relat Res, no. 391, Oct. 2001, pp. 224–33.
Rizzo M, Ghert MA, Harrelson JM, Scully SP. Chondrosarcoma of bone: analysis of 108 cases and evaluation for predictors of outcome. Clin Orthop Relat Res. 2001 Oct;(391):224–233.
Journal cover image

Published In

Clin Orthop Relat Res

ISSN

0009-921X

Publication Date

October 2001

Issue

391

Start / End Page

224 / 233

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Retrospective Studies
  • Prognosis
  • Orthopedics
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Chondrosarcoma