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Combined treatment approaches in regionally advanced bladder cancer.

Publication ,  Journal Article
Walther, PJ
Published in: Urol Clin North Am
November 1992

Multimodal therapy for locally advanced bladder carcinoma is being pursued in a wide diversity of protocols at this same time. While a number of innovative approaches are being explored, neoadjuvant and adjuvant chemotherapy in conjunction with cystectomy remains the dominant approach. The M-VAC regimen has become the dominant combination for the treatment of advanced bladder cancer; its use in an adjunctive setting is a logical progression. Although it is capable of effecting a response in the primary bladder lesion in a high percentage of cases, it is still not known whether survival will be enhanced. The use of radiosensitizing cytotoxics in conjunction with neoadjuvant chemotherapy, when combined with external-beam radiotherapy, is a provocative new approach that attempts to achieve both bladder salvage and enhanced patient survival. Completion of well-designed randomized studies will be necessary to determine whether these therapeutic innovations will yield any clinical benefit.

Duke Scholars

Published In

Urol Clin North Am

ISSN

0094-0143

Publication Date

November 1992

Volume

19

Issue

4

Start / End Page

761 / 774

Location

United States

Related Subject Headings

  • Vinblastine
  • Urology & Nephrology
  • Urinary Bladder Neoplasms
  • Radiation-Sensitizing Agents
  • Methotrexate
  • Humans
  • Doxorubicin
  • Cystectomy
  • Combined Modality Therapy
  • Cisplatin
 

Citation

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ICMJE
MLA
NLM
Walther, P. J. (1992). Combined treatment approaches in regionally advanced bladder cancer. Urol Clin North Am, 19(4), 761–774.
Walther, P. J. “Combined treatment approaches in regionally advanced bladder cancer.Urol Clin North Am 19, no. 4 (November 1992): 761–74.
Walther PJ. Combined treatment approaches in regionally advanced bladder cancer. Urol Clin North Am. 1992 Nov;19(4):761–74.
Walther, P. J. “Combined treatment approaches in regionally advanced bladder cancer.Urol Clin North Am, vol. 19, no. 4, Nov. 1992, pp. 761–74.
Walther PJ. Combined treatment approaches in regionally advanced bladder cancer. Urol Clin North Am. 1992 Nov;19(4):761–774.
Journal cover image

Published In

Urol Clin North Am

ISSN

0094-0143

Publication Date

November 1992

Volume

19

Issue

4

Start / End Page

761 / 774

Location

United States

Related Subject Headings

  • Vinblastine
  • Urology & Nephrology
  • Urinary Bladder Neoplasms
  • Radiation-Sensitizing Agents
  • Methotrexate
  • Humans
  • Doxorubicin
  • Cystectomy
  • Combined Modality Therapy
  • Cisplatin