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Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice.

Publication ,  Journal Article
Ware, JL; Paulson, DF; Mickey, GH; Webb, KS
Published in: J Urol
November 1982

Spontaneous metastasis and extensive invasiveness were observed in athymic nude mice injected with human prostatic carcinoma cells of the PC-3 line or heterotransplants of nude mouse supported PC-3 tumor. In 3 experimental series, 60, 63 and 50 per cent of the nude mice receiving subcutaneous inoculations of PC-3 cells or tumor heterotransplants developed 1 or more lymphatic tumor metastases. Examination of metaphase-arrested cells recovered from the metastatic sites confirmed the tumor origin as human in each case. Cells recovered from 1 nude mouse supported subline, MPC-3-10, frequently exhibited double minute chromosomes in addition to the typical PC-3 chromosomal profile. These observations provide the foundation for a study of the relationship between prostate carcinoma cell characteristics and lymphatic metastasis in the nude mouse.

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Published In

J Urol

DOI

ISSN

0022-5347

Publication Date

November 1982

Volume

128

Issue

5

Start / End Page

1064 / 1067

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Transplantation, Heterologous
  • Prostatic Neoplasms
  • Neoplasms, Experimental
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice
  • Male
  • Lymphatic Metastasis
  • Karyotyping
 

Citation

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Ware, J. L., Paulson, D. F., Mickey, G. H., & Webb, K. S. (1982). Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice. J Urol, 128(5), 1064–1067. https://doi.org/10.1016/s0022-5347(17)53345-5
Ware, J. L., D. F. Paulson, G. H. Mickey, and K. S. Webb. “Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice.J Urol 128, no. 5 (November 1982): 1064–67. https://doi.org/10.1016/s0022-5347(17)53345-5.
Ware JL, Paulson DF, Mickey GH, Webb KS. Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice. J Urol. 1982 Nov;128(5):1064–7.
Ware, J. L., et al. “Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice.J Urol, vol. 128, no. 5, Nov. 1982, pp. 1064–67. Pubmed, doi:10.1016/s0022-5347(17)53345-5.
Ware JL, Paulson DF, Mickey GH, Webb KS. Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice. J Urol. 1982 Nov;128(5):1064–1067.
Journal cover image

Published In

J Urol

DOI

ISSN

0022-5347

Publication Date

November 1982

Volume

128

Issue

5

Start / End Page

1064 / 1067

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Transplantation, Heterologous
  • Prostatic Neoplasms
  • Neoplasms, Experimental
  • Neoplasm Transplantation
  • Mice, Nude
  • Mice
  • Male
  • Lymphatic Metastasis
  • Karyotyping