Spontaneous metastasis of cells of the human prostate carcinoma cell line PC-3 in athymic nude mice.
Spontaneous metastasis and extensive invasiveness were observed in athymic nude mice injected with human prostatic carcinoma cells of the PC-3 line or heterotransplants of nude mouse supported PC-3 tumor. In 3 experimental series, 60, 63 and 50 per cent of the nude mice receiving subcutaneous inoculations of PC-3 cells or tumor heterotransplants developed 1 or more lymphatic tumor metastases. Examination of metaphase-arrested cells recovered from the metastatic sites confirmed the tumor origin as human in each case. Cells recovered from 1 nude mouse supported subline, MPC-3-10, frequently exhibited double minute chromosomes in addition to the typical PC-3 chromosomal profile. These observations provide the foundation for a study of the relationship between prostate carcinoma cell characteristics and lymphatic metastasis in the nude mouse.
Duke Scholars
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Related Subject Headings
- Urology & Nephrology
- Transplantation, Heterologous
- Prostatic Neoplasms
- Neoplasms, Experimental
- Neoplasm Transplantation
- Mice, Nude
- Mice
- Male
- Lymphatic Metastasis
- Karyotyping
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Urology & Nephrology
- Transplantation, Heterologous
- Prostatic Neoplasms
- Neoplasms, Experimental
- Neoplasm Transplantation
- Mice, Nude
- Mice
- Male
- Lymphatic Metastasis
- Karyotyping