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The effects of castration on adrenal testosterone secretion in men with prostatic carcinoma.

Publication ,  Journal Article
Sanford, EJ; Paulson, DF; Rohner, TJ; Santen, RJ; Bardin, CW
Published in: J Urol
December 1977

Selective adrenal vein catheterization was done on intact and castrated men with prostatic carcinoma. Adrenal to peripheral venous testosterone gradients were observed in all patients, indicating adrenal production of this hormone. No compensatory adrenal production of testosterone was noted during a 17-month period after orchiectomy. The data suggest that the human adrenal in castrates produces testosterone, which may explain why adrenal ablation can offer palliation in some patients with prostatic carcinoma.

Duke Scholars

Published In

J Urol

DOI

ISSN

0022-5347

Publication Date

December 1977

Volume

118

Issue

6

Start / End Page

1019 / 1021

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Testosterone
  • Prostatic Neoplasms
  • Palliative Care
  • Male
  • Humans
  • Catheterization
  • Castration
  • Adrenal Glands
  • 3202 Clinical sciences
 

Citation

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ICMJE
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Sanford, E. J., Paulson, D. F., Rohner, T. J., Santen, R. J., & Bardin, C. W. (1977). The effects of castration on adrenal testosterone secretion in men with prostatic carcinoma. J Urol, 118(6), 1019–1021. https://doi.org/10.1016/s0022-5347(17)58283-x
Sanford, E. J., D. F. Paulson, T. J. Rohner, R. J. Santen, and C. W. Bardin. “The effects of castration on adrenal testosterone secretion in men with prostatic carcinoma.J Urol 118, no. 6 (December 1977): 1019–21. https://doi.org/10.1016/s0022-5347(17)58283-x.
Sanford EJ, Paulson DF, Rohner TJ, Santen RJ, Bardin CW. The effects of castration on adrenal testosterone secretion in men with prostatic carcinoma. J Urol. 1977 Dec;118(6):1019–21.
Sanford, E. J., et al. “The effects of castration on adrenal testosterone secretion in men with prostatic carcinoma.J Urol, vol. 118, no. 6, Dec. 1977, pp. 1019–21. Pubmed, doi:10.1016/s0022-5347(17)58283-x.
Sanford EJ, Paulson DF, Rohner TJ, Santen RJ, Bardin CW. The effects of castration on adrenal testosterone secretion in men with prostatic carcinoma. J Urol. 1977 Dec;118(6):1019–1021.
Journal cover image

Published In

J Urol

DOI

ISSN

0022-5347

Publication Date

December 1977

Volume

118

Issue

6

Start / End Page

1019 / 1021

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Testosterone
  • Prostatic Neoplasms
  • Palliative Care
  • Male
  • Humans
  • Catheterization
  • Castration
  • Adrenal Glands
  • 3202 Clinical sciences