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Differential responsivity of monocyte cytokine and adhesion proteins in high- and low-hostile humans.

Publication ,  Journal Article
Williams, RB; Sasaki, M; Lewis, JG; Kuhn, CM; Schanberg, SM; Suarez, EC; Feaganes, JR; Adams, DO
Published in: Int J Behav Med
1997

This study tested the general hypothesis that high- and low-hostile respondents would show different patterns of change in monocyte cytokine and adhesion protein (MCAP) expression in response to pharmacologically induced alterations in sympathetic nervous system (SNS) and parasympathetic nervous system (PNS) balance. On 3 separate days, 4 high- and 4 low-hostile respondents received isoproterenol infusions after saline, atropine (PNS blockade), or neostigmine (PNS stimulation) pre-treatment. Dual color flow cytometry with fluorescently labeled monoclonal antibodies to CD 14 (monocyte market), interleukin-1, leukocyte function activator (LFA-1), Class II major histocompatibility complex (MHC-II), and tumor necrosis factor was used to quantify cytokine and adhesion protein expression on monocytes in blood samples drawn before and after the combination drug infusions on the 3 test days in each respondents. Following PNS stimulation and istoproterenol infusion there was a decrease (compared to saline pretreatment) in MHC II expression in high hostiles that was significantly (p<.02) different from an increase in low hostiles. A similar trend (p = .08) was seen for LFA-1 expression, with high hostiles showing an increase and low hostiles a decrease. These findings support the broad hypothesis that high-and low-hostile respondents will show different MCAP responses to pharmacologically induced alterations in SNS-PNS balance. Such differences could contribute to accelerated atherogenesis among high-hostile individuals.

Duke Scholars

Published In

Int J Behav Med

DOI

ISSN

1070-5503

Publication Date

1997

Volume

4

Issue

3

Start / End Page

264 / 272

Location

England

Related Subject Headings

  • Public Health
  • 5202 Biological psychology
  • 4206 Public health
  • 3901 Curriculum and pedagogy
  • 1701 Psychology
  • 1117 Public Health and Health Services
 

Citation

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Williams, R. B., Sasaki, M., Lewis, J. G., Kuhn, C. M., Schanberg, S. M., Suarez, E. C., … Adams, D. O. (1997). Differential responsivity of monocyte cytokine and adhesion proteins in high- and low-hostile humans. Int J Behav Med, 4(3), 264–272. https://doi.org/10.1207/s15327558ijbm0403_5
Williams, R. B., M. Sasaki, J. G. Lewis, C. M. Kuhn, S. M. Schanberg, E. C. Suarez, J. R. Feaganes, and D. O. Adams. “Differential responsivity of monocyte cytokine and adhesion proteins in high- and low-hostile humans.Int J Behav Med 4, no. 3 (1997): 264–72. https://doi.org/10.1207/s15327558ijbm0403_5.
Williams RB, Sasaki M, Lewis JG, Kuhn CM, Schanberg SM, Suarez EC, et al. Differential responsivity of monocyte cytokine and adhesion proteins in high- and low-hostile humans. Int J Behav Med. 1997;4(3):264–72.
Williams, R. B., et al. “Differential responsivity of monocyte cytokine and adhesion proteins in high- and low-hostile humans.Int J Behav Med, vol. 4, no. 3, 1997, pp. 264–72. Pubmed, doi:10.1207/s15327558ijbm0403_5.
Williams RB, Sasaki M, Lewis JG, Kuhn CM, Schanberg SM, Suarez EC, Feaganes JR, Adams DO. Differential responsivity of monocyte cytokine and adhesion proteins in high- and low-hostile humans. Int J Behav Med. 1997;4(3):264–272.
Journal cover image

Published In

Int J Behav Med

DOI

ISSN

1070-5503

Publication Date

1997

Volume

4

Issue

3

Start / End Page

264 / 272

Location

England

Related Subject Headings

  • Public Health
  • 5202 Biological psychology
  • 4206 Public health
  • 3901 Curriculum and pedagogy
  • 1701 Psychology
  • 1117 Public Health and Health Services