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Endocrine responses to mother-infant separation in developing rats.

Publication ,  Journal Article
Kuhn, CM; Pauk, J; Schanberg, SM
Published in: Dev Psychobiol
July 1990

Separation of neonatal rat pups from the dam have been reported to elicit two endocrine responses in the pup: a fall in growth hormone secretion and a rise in corticosterone secretion. However, the temporal, ontogenetic, and behavioral determinants of these responses have not been compared. In the present study, we report that these two responses can be differentiated on each of these criteria. Growth hormone secretion falls rapidly immediately upon separation of pups from the dam, while robust rises in corticosterone secretion are delayed for many hours. In addition, growth hormone responses are observed earlier in ontogeny. Finally, active maternal behavior is required for normal growth hormone secretion in 10-day-old rat pups, while passive sensory stimuli associated with the dam can significantly reduce the corticosterone response to separation.

Duke Scholars

Published In

Dev Psychobiol

DOI

ISSN

0012-1630

Publication Date

July 1990

Volume

23

Issue

5

Start / End Page

395 / 410

Location

United States

Related Subject Headings

  • Rats
  • Maternal Deprivation
  • Maternal Behavior
  • Growth Hormone
  • Corticosterone
  • Behavioral Science & Comparative Psychology
  • Arousal
  • Animals, Newborn
  • Animals
  • 5202 Biological psychology
 

Citation

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Kuhn, C. M., Pauk, J., & Schanberg, S. M. (1990). Endocrine responses to mother-infant separation in developing rats. Dev Psychobiol, 23(5), 395–410. https://doi.org/10.1002/dev.420230503
Kuhn, C. M., J. Pauk, and S. M. Schanberg. “Endocrine responses to mother-infant separation in developing rats.Dev Psychobiol 23, no. 5 (July 1990): 395–410. https://doi.org/10.1002/dev.420230503.
Kuhn CM, Pauk J, Schanberg SM. Endocrine responses to mother-infant separation in developing rats. Dev Psychobiol. 1990 Jul;23(5):395–410.
Kuhn, C. M., et al. “Endocrine responses to mother-infant separation in developing rats.Dev Psychobiol, vol. 23, no. 5, July 1990, pp. 395–410. Pubmed, doi:10.1002/dev.420230503.
Kuhn CM, Pauk J, Schanberg SM. Endocrine responses to mother-infant separation in developing rats. Dev Psychobiol. 1990 Jul;23(5):395–410.
Journal cover image

Published In

Dev Psychobiol

DOI

ISSN

0012-1630

Publication Date

July 1990

Volume

23

Issue

5

Start / End Page

395 / 410

Location

United States

Related Subject Headings

  • Rats
  • Maternal Deprivation
  • Maternal Behavior
  • Growth Hormone
  • Corticosterone
  • Behavioral Science & Comparative Psychology
  • Arousal
  • Animals, Newborn
  • Animals
  • 5202 Biological psychology