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Age-related differences in the chronic and acute response to cocaine in the rat.

Publication ,  Journal Article
Bowman, BP; Kuhn, CM
Published in: Dev Psychobiol
November 1996

Behavioral sensitization is known to occur in adult animals after the chronic intermittent administration of cocaine. Dopaminergic pathways in the brain, such as the nigrostriatal and mesoaccumbens projections play a vital role in this phenomenon. These pathways are rudimentary in the 1st week of life, indicating that the developing animal may be unable to respond to cocaine in the same manner as an adult. In the present study, we report that the acute response to cocaine is remarkably similar between week-old and adult rats. Pups do not, however, show locomotor sensitization to acute cocaine after chronic cocaine-administration as adults.

Duke Scholars

Published In

Dev Psychobiol

DOI

ISSN

0012-1630

Publication Date

November 1996

Volume

29

Issue

7

Start / End Page

597 / 611

Location

United States

Related Subject Headings

  • Rats
  • Male
  • Locomotion
  • Female
  • Cocaine
  • Brain
  • Behavioral Science & Comparative Psychology
  • Behavior, Animal
  • Animals
  • Aging
 

Citation

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Bowman, B. P., & Kuhn, C. M. (1996). Age-related differences in the chronic and acute response to cocaine in the rat. Dev Psychobiol, 29(7), 597–611. https://doi.org/10.1002/(SICI)1098-2302(199611)29:7<597::AID-DEV4>3.0.CO;2-P
Bowman, B. P., and C. M. Kuhn. “Age-related differences in the chronic and acute response to cocaine in the rat.Dev Psychobiol 29, no. 7 (November 1996): 597–611. https://doi.org/10.1002/(SICI)1098-2302(199611)29:7<597::AID-DEV4>3.0.CO;2-P.
Bowman BP, Kuhn CM. Age-related differences in the chronic and acute response to cocaine in the rat. Dev Psychobiol. 1996 Nov;29(7):597–611.
Bowman, B. P., and C. M. Kuhn. “Age-related differences in the chronic and acute response to cocaine in the rat.Dev Psychobiol, vol. 29, no. 7, Nov. 1996, pp. 597–611. Pubmed, doi:10.1002/(SICI)1098-2302(199611)29:7<597::AID-DEV4>3.0.CO;2-P.
Bowman BP, Kuhn CM. Age-related differences in the chronic and acute response to cocaine in the rat. Dev Psychobiol. 1996 Nov;29(7):597–611.
Journal cover image

Published In

Dev Psychobiol

DOI

ISSN

0012-1630

Publication Date

November 1996

Volume

29

Issue

7

Start / End Page

597 / 611

Location

United States

Related Subject Headings

  • Rats
  • Male
  • Locomotion
  • Female
  • Cocaine
  • Brain
  • Behavioral Science & Comparative Psychology
  • Behavior, Animal
  • Animals
  • Aging