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Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets.

Publication ,  Journal Article
Wencel, HE; Smothers, C; Opara, EC; Kuhn, CM; Feinglos, MN; Surwit, RS
Published in: Physiol Behav
June 1995

The C57BL/6J mouse develops obesity and diabetes in response to a high-fat, high-simple carbohydrate diet. To determine the dynamics of glucose-induced insulin release in this animal model of NIDDM, we studied the acute insulin response to glucose of perifused islets in C57BL/6J (diabetes-prone) and A/J (diabetes-resistant) mice fed a normal control diet and of others fed a diabetogenic diet. The insulin response of normal C57BL/6J islets was almost monophasic, with a deficiency in the second phase during high glucose stimulation when compared to that of A/J control islets. The defect in C57BL/6J mice was exaggerated in animals fed a diabetogenic diet. It is suggested that a latent deficiency of second phase insulin release may contribute to the development of the diet-induced syndrome in this model.

Duke Scholars

Published In

Physiol Behav

DOI

ISSN

0031-9384

Publication Date

June 1995

Volume

57

Issue

6

Start / End Page

1215 / 1220

Location

United States

Related Subject Headings

  • Stimulation, Chemical
  • Mice, Inbred Strains
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Islets of Langerhans
  • Insulin Secretion
  • Insulin
  • In Vitro Techniques
  • Glucose
 

Citation

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Wencel, H. E., Smothers, C., Opara, E. C., Kuhn, C. M., Feinglos, M. N., & Surwit, R. S. (1995). Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets. Physiol Behav, 57(6), 1215–1220. https://doi.org/10.1016/0031-9384(95)00022-b
Wencel, H. E., C. Smothers, E. C. Opara, C. M. Kuhn, M. N. Feinglos, and R. S. Surwit. “Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets.Physiol Behav 57, no. 6 (June 1995): 1215–20. https://doi.org/10.1016/0031-9384(95)00022-b.
Wencel HE, Smothers C, Opara EC, Kuhn CM, Feinglos MN, Surwit RS. Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets. Physiol Behav. 1995 Jun;57(6):1215–20.
Wencel, H. E., et al. “Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets.Physiol Behav, vol. 57, no. 6, June 1995, pp. 1215–20. Pubmed, doi:10.1016/0031-9384(95)00022-b.
Wencel HE, Smothers C, Opara EC, Kuhn CM, Feinglos MN, Surwit RS. Impaired second phase insulin response of diabetes-prone C57BL/6J mouse islets. Physiol Behav. 1995 Jun;57(6):1215–1220.
Journal cover image

Published In

Physiol Behav

DOI

ISSN

0031-9384

Publication Date

June 1995

Volume

57

Issue

6

Start / End Page

1215 / 1220

Location

United States

Related Subject Headings

  • Stimulation, Chemical
  • Mice, Inbred Strains
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Islets of Langerhans
  • Insulin Secretion
  • Insulin
  • In Vitro Techniques
  • Glucose