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Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin.

Publication ,  Journal Article
Blackford, SP; Little, PJ; Kuhn, CM
Published in: Endocrinology
December 1992

The present study explores developmental changes in mu- and kappa-opiate receptor control of PRL secretion. The ontogeny of mu- and kappa-receptor function was determined by assessing the PRL response to the mu-agonist sufentanil (SUF) and the kappa-agonist U50488 in 5-, 10-, 15-, 20-, and 60-day-old rats. Both mu- and kappa-agonists stimulated PRL secretion at all ages. The selectivity of the mu- and kappa-agonists was confirmed by selective blockade with their respective antagonists (beta-funaltrexamine and nor-binaltorphimine). Serotonin mediation of opiate-induced changes in PRL secretion was explored across ontogeny by testing cyproheptadine (CYPRO) blockade of agonist responses in 5-, 10-, 20-, and 60-day-old rats. CYPRO attenuated the PRL response to the mu-agonist SUF in 20- and 60-day-old rats, but not in the 5- or 10-day-old pups. CYPRO did not block the kappa-agonist U50488 at any age. Similarly, pretreatment with parachlorophenylalaine lowered the PRL response to SUF in 60-day-old rats, but not in 10-day-old rats. These results support previous reports of a serotonin-mediated mu control of PRL secretion that develops by day 20 and a kappa control of PRL secretion that is independent of serotonin at all ages. These findings also suggest that a previously reported serotonin-independent mu-receptor-mediated control of PRL secretion can be stimulated early in ontogeny.

Duke Scholars

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

December 1992

Volume

131

Issue

6

Start / End Page

2891 / 2897

Location

United States

Related Subject Headings

  • Sufentanil
  • Serotonin
  • Receptors, Opioid, mu
  • Receptors, Opioid, kappa
  • Rats, Sprague-Dawley
  • Rats
  • Pyrrolidines
  • Prolactin
  • Naltrexone
  • Male
 

Citation

APA
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ICMJE
MLA
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Blackford, S. P., Little, P. J., & Kuhn, C. M. (1992). Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin. Endocrinology, 131(6), 2891–2897. https://doi.org/10.1210/endo.131.6.1332851
Blackford, S. P., P. J. Little, and C. M. Kuhn. “Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin.Endocrinology 131, no. 6 (December 1992): 2891–97. https://doi.org/10.1210/endo.131.6.1332851.
Blackford SP, Little PJ, Kuhn CM. Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin. Endocrinology. 1992 Dec;131(6):2891–7.
Blackford, S. P., et al. “Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin.Endocrinology, vol. 131, no. 6, Dec. 1992, pp. 2891–97. Pubmed, doi:10.1210/endo.131.6.1332851.
Blackford SP, Little PJ, Kuhn CM. Mu- and kappa-opiate receptor control of prolactin secretion in rats: ontogeny and interaction with serotonin. Endocrinology. 1992 Dec;131(6):2891–2897.
Journal cover image

Published In

Endocrinology

DOI

ISSN

0013-7227

Publication Date

December 1992

Volume

131

Issue

6

Start / End Page

2891 / 2897

Location

United States

Related Subject Headings

  • Sufentanil
  • Serotonin
  • Receptors, Opioid, mu
  • Receptors, Opioid, kappa
  • Rats, Sprague-Dawley
  • Rats
  • Pyrrolidines
  • Prolactin
  • Naltrexone
  • Male