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Glipizide stimulates sympathetic outflow in diabetes-prone mice.

Publication ,  Journal Article
Kuhn, CM; Surwit, RS; Feinglos, MN
Published in: Life Sci
1995

The purpose of the present study was to determine if the oral hypoglycemic agent glipizide influenced sympathetic outflow in diabetes-prone mice. C57BL/6 (diabetes-prone) and diabetes-resistant (A/J) were treated with saline or glipizide, and sympathetic outflow determined by the fall in organ norepinephrine content after synthesis inhibition with alpha-methyl-para-tyrosine. Sympathetic outflow to the liver and pancreas were slower in Bl/6 mice than in control A/J. Glipizide increased sympathetic outflow to the pancreas in both strains of mice, but did not influence outflow to other organs significantly. The results of this study suggest that glipizide can influence central glucoregulatory mechanisms after peripheral administration.

Duke Scholars

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1995

Volume

56

Issue

9

Start / End Page

661 / 666

Location

Netherlands

Related Subject Headings

  • Pharmacology & Pharmacy
  • Pancreas
  • Norepinephrine
  • Myocardium
  • Mice, Inbred C57BL
  • Mice, Inbred A
  • Mice
  • Methyltyrosines
  • Liver
  • Glipizide
 

Citation

APA
Chicago
ICMJE
MLA
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Kuhn, C. M., Surwit, R. S., & Feinglos, M. N. (1995). Glipizide stimulates sympathetic outflow in diabetes-prone mice. Life Sci, 56(9), 661–666. https://doi.org/10.1016/0024-3205(94)00499-i
Kuhn, C. M., R. S. Surwit, and M. N. Feinglos. “Glipizide stimulates sympathetic outflow in diabetes-prone mice.Life Sci 56, no. 9 (1995): 661–66. https://doi.org/10.1016/0024-3205(94)00499-i.
Kuhn CM, Surwit RS, Feinglos MN. Glipizide stimulates sympathetic outflow in diabetes-prone mice. Life Sci. 1995;56(9):661–6.
Kuhn, C. M., et al. “Glipizide stimulates sympathetic outflow in diabetes-prone mice.Life Sci, vol. 56, no. 9, 1995, pp. 661–66. Pubmed, doi:10.1016/0024-3205(94)00499-i.
Kuhn CM, Surwit RS, Feinglos MN. Glipizide stimulates sympathetic outflow in diabetes-prone mice. Life Sci. 1995;56(9):661–666.
Journal cover image

Published In

Life Sci

DOI

ISSN

0024-3205

Publication Date

1995

Volume

56

Issue

9

Start / End Page

661 / 666

Location

Netherlands

Related Subject Headings

  • Pharmacology & Pharmacy
  • Pancreas
  • Norepinephrine
  • Myocardium
  • Mice, Inbred C57BL
  • Mice, Inbred A
  • Mice
  • Methyltyrosines
  • Liver
  • Glipizide