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Glycemic response to stress is altered in euglycemic Pima Indians.

Publication ,  Journal Article
Esposito-Del Puente, A; Lillioja, S; Bogardus, C; McCubbin, JA; Feinglos, MN; Kuhn, CM; Surwit, RS
Published in: Int J Obes Relat Metab Disord
November 1994

The aim of this work was to study the effects of a computer-driven mental arithmetic task on blood glucose in a group of four male and four female euglycemic Caucasians and a group of seven male and six female euglycemic Pima Indians. Approximately 60% of euglycemic Pima Indian Native Americans eventually develop type 2 diabetes, while only 5% of Caucasians develop the disease. All subjects had normal glucose tolerance. Subjects were given a standard breakfast; 2 h later, they were given a computerized mental arithmetic stress test for 10 min. Before, during and after the test, several variables were analyzed, including serum concentrations of glucose, insulin, glucagon and plasma cortisol and catecholamines. Heart rate, systolic and diastolic blood pressure and all the stress hormones increased during stress and decreased during recovery in all subjects. Blood glucose consistently declined one hour after the meal in all subjects. However, while it continued to decline following stress in seven out of eight Caucasian subjects, it consistently increased during and following stress in 10 out of 13 Pima Indians. Fasting serum glucose in Pima Indians and Caucasians was respectively 5.07 + 0.08 mM and 5.04 + 0.09 mM. Two-hour post-prandial values were 5.63 + 0.22 mM and 5.48 + 0.19 mM respectively, whereas post-stress values were 6.15 + 0.19 mM for Pima Indians and 5.22 + 0.20 mM for Caucasians. Both serum glucose means following stress (t = 3.1, P < 0.005) and the direction of change in serum glucose in response to mental arithmetic (chi 2 = 8.2, P < 0.01) clearly differentiated Pimas from Caucasians.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Int J Obes Relat Metab Disord

Publication Date

November 1994

Volume

18

Issue

11

Start / End Page

766 / 770

Location

England

Related Subject Headings

  • White People
  • Stress, Psychological
  • Software
  • Risk Factors
  • Radioimmunoassay
  • Prevalence
  • Obesity
  • Mathematics
  • Male
  • Insulin Resistance
 

Citation

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Esposito-Del Puente, A., Lillioja, S., Bogardus, C., McCubbin, J. A., Feinglos, M. N., Kuhn, C. M., & Surwit, R. S. (1994). Glycemic response to stress is altered in euglycemic Pima Indians. Int J Obes Relat Metab Disord, 18(11), 766–770.
Esposito-Del Puente, A., S. Lillioja, C. Bogardus, J. A. McCubbin, M. N. Feinglos, C. M. Kuhn, and R. S. Surwit. “Glycemic response to stress is altered in euglycemic Pima Indians.Int J Obes Relat Metab Disord 18, no. 11 (November 1994): 766–70.
Esposito-Del Puente A, Lillioja S, Bogardus C, McCubbin JA, Feinglos MN, Kuhn CM, et al. Glycemic response to stress is altered in euglycemic Pima Indians. Int J Obes Relat Metab Disord. 1994 Nov;18(11):766–70.
Esposito-Del Puente, A., et al. “Glycemic response to stress is altered in euglycemic Pima Indians.Int J Obes Relat Metab Disord, vol. 18, no. 11, Nov. 1994, pp. 766–70.
Esposito-Del Puente A, Lillioja S, Bogardus C, McCubbin JA, Feinglos MN, Kuhn CM, Surwit RS. Glycemic response to stress is altered in euglycemic Pima Indians. Int J Obes Relat Metab Disord. 1994 Nov;18(11):766–770.

Published In

Int J Obes Relat Metab Disord

Publication Date

November 1994

Volume

18

Issue

11

Start / End Page

766 / 770

Location

England

Related Subject Headings

  • White People
  • Stress, Psychological
  • Software
  • Risk Factors
  • Radioimmunoassay
  • Prevalence
  • Obesity
  • Mathematics
  • Male
  • Insulin Resistance