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Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus.

Publication ,  Journal Article
Dodds Ashley, ES; Carroll, DN; Engemann, JJ; Harris, AD; Fowler, VG; Sexton, DJ; Kaye, KS
Published in: Clin Infect Dis
June 1, 2004

Risk factors for developing postoperative mediastinitis (POM) due to methicillin-resistant Staphylococcus aureus (MRSA) were analyzed in a case-case control study of patients who underwent median sternotomy during the period from 1994 through 2000. Three patient groups were studied. The first consisted of 64 patients with POM due to MRSA; the second consisted of 79 patients with POM due to methicillin-susceptible S. aureus (MSSA); and the third consisted of 80 uninfected control patients. In multivariable analysis, patients who were diabetic (adjusted OR, 2.86; 95% CI, 1.22-6.70), female (OR, 2.70; 95% CI, 1.25-5.88), and >70 years old (OR, 3.43; 95% CI, 1.53-7.71) were more likely to develop POM due to MRSA. In contrast, the only independent risk factor associated with POM due to MSSA was obesity (OR, 2.49; 95% CI, 1.25-4.96). Antimicrobial prophylaxis consisted primarily of cephalosporin antibiotics (administered to 97% of the patients). Changes in perioperative antimicrobial prophylaxis, in addition to other interventions, should be considered for prevention of POM due to MRSA in targeted, high-risk populations.

Duke Scholars

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

June 1, 2004

Volume

38

Issue

11

Start / End Page

1555 / 1560

Location

United States

Related Subject Headings

  • Surgical Wound Infection
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Sex Factors
  • Risk Factors
  • Obesity
  • Middle Aged
  • Microbiology
  • Microbial Sensitivity Tests
  • Methicillin Resistance
 

Citation

APA
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ICMJE
MLA
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Dodds Ashley, E. S., Carroll, D. N., Engemann, J. J., Harris, A. D., Fowler, V. G., Sexton, D. J., & Kaye, K. S. (2004). Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus. Clin Infect Dis, 38(11), 1555–1560. https://doi.org/10.1086/420819
Dodds Ashley, E. S., D. N. Carroll, J. J. Engemann, A. D. Harris, V. G. Fowler, D. J. Sexton, and K. S. Kaye. “Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus.Clin Infect Dis 38, no. 11 (June 1, 2004): 1555–60. https://doi.org/10.1086/420819.
Dodds Ashley ES, Carroll DN, Engemann JJ, Harris AD, Fowler VG, Sexton DJ, et al. Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2004 Jun 1;38(11):1555–60.
Dodds Ashley, E. S., et al. “Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus.Clin Infect Dis, vol. 38, no. 11, June 2004, pp. 1555–60. Pubmed, doi:10.1086/420819.
Dodds Ashley ES, Carroll DN, Engemann JJ, Harris AD, Fowler VG, Sexton DJ, Kaye KS. Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus. Clin Infect Dis. 2004 Jun 1;38(11):1555–1560.
Journal cover image

Published In

Clin Infect Dis

DOI

EISSN

1537-6591

Publication Date

June 1, 2004

Volume

38

Issue

11

Start / End Page

1555 / 1560

Location

United States

Related Subject Headings

  • Surgical Wound Infection
  • Staphylococcus aureus
  • Staphylococcal Infections
  • Sex Factors
  • Risk Factors
  • Obesity
  • Middle Aged
  • Microbiology
  • Microbial Sensitivity Tests
  • Methicillin Resistance