Diversification of Ig superfamily genes in an invertebrate.
Publication
, Journal Article
Zhang, S-M; Adema, CM; Kepler, TB; Loker, ES
Published in: Science
July 9, 2004
The freshwater snail Biomphalaria glabrata possesses a diverse family of fibrinogen-related proteins (FREPs), hemolymph polypeptides that consist of one or two amino-terminal immunoglobulin superfamily (IgSF) domains and a carboxyl-terminal fibrinogen domain. Here, we show that the IgSF1 domain of the FREP3 subfamily is diversified at the genomic level at higher rates than those recorded for control genes. All sequence variants are derived from a small set of nine source sequences by point mutation and recombinatorial processes. Diverse FREP3 transcripts are also produced. We hypothesize a mechanism present in snails that is capable of diversifying molecules involved in internal defense.
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Published In
Science
DOI
EISSN
1095-9203
Publication Date
July 9, 2004
Volume
305
Issue
5681
Start / End Page
251 / 254
Location
United States
Related Subject Headings
- Recombination, Genetic
- Protein Structure, Tertiary
- Polymerase Chain Reaction
- Point Mutation
- Molecular Sequence Data
- Immunoglobulins
- Hemocytes
- Genetic Variation
- Genes, Immunoglobulin
- General Science & Technology
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhang, S.-M., Adema, C. M., Kepler, T. B., & Loker, E. S. (2004). Diversification of Ig superfamily genes in an invertebrate. Science, 305(5681), 251–254. https://doi.org/10.1126/science.1088069
Zhang, Si-Ming, Coen M. Adema, Thomas B. Kepler, and Eric S. Loker. “Diversification of Ig superfamily genes in an invertebrate.” Science 305, no. 5681 (July 9, 2004): 251–54. https://doi.org/10.1126/science.1088069.
Zhang S-M, Adema CM, Kepler TB, Loker ES. Diversification of Ig superfamily genes in an invertebrate. Science. 2004 Jul 9;305(5681):251–4.
Zhang, Si-Ming, et al. “Diversification of Ig superfamily genes in an invertebrate.” Science, vol. 305, no. 5681, July 2004, pp. 251–54. Pubmed, doi:10.1126/science.1088069.
Zhang S-M, Adema CM, Kepler TB, Loker ES. Diversification of Ig superfamily genes in an invertebrate. Science. 2004 Jul 9;305(5681):251–254.
Published In
Science
DOI
EISSN
1095-9203
Publication Date
July 9, 2004
Volume
305
Issue
5681
Start / End Page
251 / 254
Location
United States
Related Subject Headings
- Recombination, Genetic
- Protein Structure, Tertiary
- Polymerase Chain Reaction
- Point Mutation
- Molecular Sequence Data
- Immunoglobulins
- Hemocytes
- Genetic Variation
- Genes, Immunoglobulin
- General Science & Technology