Humoral antibody response and tumor transplantation resistance elicited by fetal tissues in mice.
Immune responses to fetal antigen immunization were studied in C57BL/6 (B6), C3H/HeN (C3H), and BALB/c (BALB) mice. In tests by the isotopic antiglobulin technique, the mice could be grouped in three classes according to their antibody responses: good responders (B6), poor responders (C3H), and nonresponders (BALB). In tumor transplantation experiments, protection against syngeneic tumor-cell challenge, after fetal tissue immunization, was observed only with B6 mice. In addition, experiments on B6 mice showed that resistance to tumor challenge after fetal tissue immunization depended on the quantitative expression of fetal antigens by the tumor cells. Our results indicated that, in addition to other well-known factors, the effectiveness of fetal tissue immunization in tumor-challenge resistance depended on both host responsiveness and the amount of fetal antigen expressed by the tumor cells.
Duke Scholars
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Related Subject Headings
- Oncology & Carcinogenesis
- Neoplasms, Experimental
- Neoplasm Transplantation
- Mice, Inbred C57BL
- Mice, Inbred C3H
- Mice, Inbred BALB C
- Mice
- Immunization
- Fetus
- Antigens
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Oncology & Carcinogenesis
- Neoplasms, Experimental
- Neoplasm Transplantation
- Mice, Inbred C57BL
- Mice, Inbred C3H
- Mice, Inbred BALB C
- Mice
- Immunization
- Fetus
- Antigens