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Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms.

Publication ,  Journal Article
Seneca, H; Grant, JP
Published in: J Am Geriatr Soc
November 1975

A review of the literature reveals that glucocorticoids have: 1) a protective effect both in vitro and in vivo against bacterial endotoxins and exotoxins, and 2) a protective or therapeutic effect in sepsis/shock caused by Gram-negative microorganisms. At the Columbia Presbyterian Medical Center, the 1968-1973 mortality rate for general sepsis/shock due to Gram-negative organisms was 16.6 percent and for urologic sepsis/shock 15.3 percent. This low rate was the result of early diagnosis and early use of massive dosages of glucocorticoids (hydrocortisone, methylprednisolone, dexamethasone), beta-adrenergic isoproterenol, and bactericidal antibiotics (gentamicin, kanamycin, carbenicillin, cephalothin-cefazolin, ampicillin).

Duke Scholars

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

November 1975

Volume

23

Issue

11

Start / End Page

493 / 502

Location

United States

Related Subject Headings

  • Shock, Septic
  • Sepsis
  • New York City
  • Microcirculation
  • Methylprednisolone
  • Kanamycin
  • Isoproterenol
  • Hydrocortisone
  • Humans
  • Glucocorticoids
 

Citation

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Seneca, H., & Grant, J. P. (1975). Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms. J Am Geriatr Soc, 23(11), 493–502. https://doi.org/10.1111/j.1532-5415.1975.tb00895.x
Seneca, H., and J. P. Grant. “Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms.J Am Geriatr Soc 23, no. 11 (November 1975): 493–502. https://doi.org/10.1111/j.1532-5415.1975.tb00895.x.
Seneca H, Grant JP. Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms. J Am Geriatr Soc. 1975 Nov;23(11):493–502.
Seneca, H., and J. P. Grant. “Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms.J Am Geriatr Soc, vol. 23, no. 11, Nov. 1975, pp. 493–502. Pubmed, doi:10.1111/j.1532-5415.1975.tb00895.x.
Seneca H, Grant JP. Glucocorticoid therapy in sepsis/shock caused by gram-negative microorganisms. J Am Geriatr Soc. 1975 Nov;23(11):493–502.
Journal cover image

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

November 1975

Volume

23

Issue

11

Start / End Page

493 / 502

Location

United States

Related Subject Headings

  • Shock, Septic
  • Sepsis
  • New York City
  • Microcirculation
  • Methylprednisolone
  • Kanamycin
  • Isoproterenol
  • Hydrocortisone
  • Humans
  • Glucocorticoids