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Effects of enteral feeding products on survival from Escherichia coli peritonitis.

Publication ,  Journal Article
Grant, AP; Grant, JP; Snyder, PJ; Chapman, G; Russell, M
Published in: J Trauma
November 1994

Male Fischer 344 rats were orally fed one of four diets (Osmolite HN, Alitraq, Impact, and Purina rodent chow). After 6 days, jejunal mucosal nitrogen content and thickness were normal in all groups. After 7 days, challenge with Escherichia coli intraperitoneally demonstrated no difference in survival for any dietary group. In a second study, acute protein-calorie malnutrition was induced by administering 5% dextrose orally for 10 days. Animals were refed for 7 days with one of the four diets. Serum albumin concentrations and intestinal mucosal nitrogen content and thickness returned to normal with each refeeding program. Challenge with E. coli after 7 days of refeeding, however, again demonstrated no difference in survival for any dietary group. Specialized enteral feeding products, containing additional amounts of arginine, glutamine, glutamate, RNA, and omega-3 fatty acids, are no more effective than a standard enteral feeding product or rat chow in maintaining intestinal anatomy or restoring anatomy following fasting. Furthermore, we found no survival advantage for the specialized products following E. coli peritonitis.

Duke Scholars

Published In

J Trauma

DOI

ISSN

0022-5282

Publication Date

November 1994

Volume

37

Issue

5

Start / End Page

778 / 785

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Protein-Energy Malnutrition
  • Peritonitis
  • Nitrogen
  • Male
  • Liver
  • Jejunum
  • Intestinal Mucosa
  • Food, Formulated
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Grant, A. P., Grant, J. P., Snyder, P. J., Chapman, G., & Russell, M. (1994). Effects of enteral feeding products on survival from Escherichia coli peritonitis. J Trauma, 37(5), 778–785. https://doi.org/10.1097/00005373-199411000-00012
Grant, A. P., J. P. Grant, P. J. Snyder, G. Chapman, and M. Russell. “Effects of enteral feeding products on survival from Escherichia coli peritonitis.J Trauma 37, no. 5 (November 1994): 778–85. https://doi.org/10.1097/00005373-199411000-00012.
Grant AP, Grant JP, Snyder PJ, Chapman G, Russell M. Effects of enteral feeding products on survival from Escherichia coli peritonitis. J Trauma. 1994 Nov;37(5):778–85.
Grant, A. P., et al. “Effects of enteral feeding products on survival from Escherichia coli peritonitis.J Trauma, vol. 37, no. 5, Nov. 1994, pp. 778–85. Pubmed, doi:10.1097/00005373-199411000-00012.
Grant AP, Grant JP, Snyder PJ, Chapman G, Russell M. Effects of enteral feeding products on survival from Escherichia coli peritonitis. J Trauma. 1994 Nov;37(5):778–785.

Published In

J Trauma

DOI

ISSN

0022-5282

Publication Date

November 1994

Volume

37

Issue

5

Start / End Page

778 / 785

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Protein-Energy Malnutrition
  • Peritonitis
  • Nitrogen
  • Male
  • Liver
  • Jejunum
  • Intestinal Mucosa
  • Food, Formulated