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The changing pattern of bacterial sepsis since the introduction of antibiotic therapy.

Publication ,  Journal Article
Seneca, H; Grant, JP
Published in: J Am Geriatr Soc
April 1976

During the six-year period, 1968-1973, sepsis developed in 1 of every 80 patients admitted to the Presbyterian Hospital, New York. In 1 of 133 patients the sepsis was due to Gram-positive organisms, and in 1 of 188 patients to Gram-negative organisms. The mortality rate for Gram-positive cases was 4.4 percent, for Gram-negative cases 19.1 percent, and for urologic cases 15.3 percent (versus 56.25 percent in 1959-1964). Data are presented on the relative incidences of involved pathogens in 1740 cases of Gram-positive sepsis /78 deaths), and in 1236 cases of Gram-negative sepsis (205 deaths). The lowering of the sepsis mortality rate has been the result of preventative measures, early diagnosis, and vigorous treatment. Treatment includes the correction of acidosis and anoxia, early administration of bactericidal antibiotics, and restoration of the microcirculation by administration of corticosteroids, beta-adrenergic drugs, and appropriate diuretics.

Duke Scholars

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

April 1976

Volume

24

Issue

4

Start / End Page

155 / 164

Location

United States

Related Subject Headings

  • Shock, Septic
  • Prognosis
  • New York City
  • Humans
  • Glucocorticoids
  • Geriatrics
  • Cross Infection
  • Bacterial Infections
  • Anti-Bacterial Agents
  • Adrenergic beta-Antagonists
 

Citation

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Seneca, H., & Grant, J. P. (1976). The changing pattern of bacterial sepsis since the introduction of antibiotic therapy. J Am Geriatr Soc, 24(4), 155–164. https://doi.org/10.1111/j.1532-5415.1976.tb04292.x
Seneca, H., and J. P. Grant. “The changing pattern of bacterial sepsis since the introduction of antibiotic therapy.J Am Geriatr Soc 24, no. 4 (April 1976): 155–64. https://doi.org/10.1111/j.1532-5415.1976.tb04292.x.
Seneca H, Grant JP. The changing pattern of bacterial sepsis since the introduction of antibiotic therapy. J Am Geriatr Soc. 1976 Apr;24(4):155–64.
Seneca, H., and J. P. Grant. “The changing pattern of bacterial sepsis since the introduction of antibiotic therapy.J Am Geriatr Soc, vol. 24, no. 4, Apr. 1976, pp. 155–64. Pubmed, doi:10.1111/j.1532-5415.1976.tb04292.x.
Seneca H, Grant JP. The changing pattern of bacterial sepsis since the introduction of antibiotic therapy. J Am Geriatr Soc. 1976 Apr;24(4):155–164.
Journal cover image

Published In

J Am Geriatr Soc

DOI

ISSN

0002-8614

Publication Date

April 1976

Volume

24

Issue

4

Start / End Page

155 / 164

Location

United States

Related Subject Headings

  • Shock, Septic
  • Prognosis
  • New York City
  • Humans
  • Glucocorticoids
  • Geriatrics
  • Cross Infection
  • Bacterial Infections
  • Anti-Bacterial Agents
  • Adrenergic beta-Antagonists