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Race and glomerulonephritis in patients with and without hepatosplenic Schistosomiasis mansoni.

Publication ,  Journal Article
Lopes, AA; Port, FK; James, SA; Silveira, MA; Martinelli, R; Brito, E; Rocha, H
Published in: Clinical nephrology
November 2002

United States investigators have shown evidence of higher susceptibility to focal segmental glomerulosclerosis (FSGS) in blacks than in whites. This association between race and FSGS has not been assessed outside the US. The present study assesses the association between race and type of glomerulonephritis in a sample of Brazilian patients, taking into account the presence of the hepatosplenic form of Schistosomiasis mansoni (HSM).Eighty patients with focal segmental glomerulosclerosis (FSGS) were compared to 50 with membranoproliferative glomerulonephritis (MPGN). The association between race (i.e. black versus white) and type of glomerulonephritis was adjusted for age, gender and HSM by logistic regression.Blacks were more likely than whites to have FSGS (as compared to MPGN), both among patients with HSM (odds ratio (OR) = 2.67; 95% confidence interval (CI) = 0.81 - 8.81) and without HSM (OR = 2.19; 95% CI = 0.79 - 6.05). After adjustment for age, gender and HSM, the odds of FSGS remained significantly greater for blacks (OR = 2.49; 95% CI = 1.05 - 5.95).The increased likelihood of FSGS in Brazilian blacks is consistent with findings from US patients. The association between race and type of glomerulonephritis was similar between patients with and without HSM. Future investigations should focus on the mediators factors that might explain these findings.

Duke Scholars

Published In

Clinical nephrology

DOI

ISSN

0301-0430

Publication Date

November 2002

Volume

58

Issue

5

Start / End Page

333 / 336

Related Subject Headings

  • White People
  • Urology & Nephrology
  • Spleen
  • Schistosomiasis mansoni
  • Schistosoma mansoni
  • Retrospective Studies
  • Male
  • Liver
  • Humans
  • Glomerulosclerosis, Focal Segmental
 

Citation

APA
Chicago
ICMJE
MLA
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Lopes, A. A., Port, F. K., James, S. A., Silveira, M. A., Martinelli, R., Brito, E., & Rocha, H. (2002). Race and glomerulonephritis in patients with and without hepatosplenic Schistosomiasis mansoni. Clinical Nephrology, 58(5), 333–336. https://doi.org/10.5414/cnp58333
Lopes, A. A., F. K. Port, S. A. James, M. A. Silveira, R. Martinelli, E. Brito, and H. Rocha. “Race and glomerulonephritis in patients with and without hepatosplenic Schistosomiasis mansoni.Clinical Nephrology 58, no. 5 (November 2002): 333–36. https://doi.org/10.5414/cnp58333.
Lopes AA, Port FK, James SA, Silveira MA, Martinelli R, Brito E, et al. Race and glomerulonephritis in patients with and without hepatosplenic Schistosomiasis mansoni. Clinical nephrology. 2002 Nov;58(5):333–6.
Lopes, A. A., et al. “Race and glomerulonephritis in patients with and without hepatosplenic Schistosomiasis mansoni.Clinical Nephrology, vol. 58, no. 5, Nov. 2002, pp. 333–36. Epmc, doi:10.5414/cnp58333.
Lopes AA, Port FK, James SA, Silveira MA, Martinelli R, Brito E, Rocha H. Race and glomerulonephritis in patients with and without hepatosplenic Schistosomiasis mansoni. Clinical nephrology. 2002 Nov;58(5):333–336.

Published In

Clinical nephrology

DOI

ISSN

0301-0430

Publication Date

November 2002

Volume

58

Issue

5

Start / End Page

333 / 336

Related Subject Headings

  • White People
  • Urology & Nephrology
  • Spleen
  • Schistosomiasis mansoni
  • Schistosoma mansoni
  • Retrospective Studies
  • Male
  • Liver
  • Humans
  • Glomerulosclerosis, Focal Segmental