Scholars@Duke publication: HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians.

HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians.

Publication , Journal Article

Ferrari, G; Currier, JR; Harris, ME; Finkelstein, S; de Oliveira, A; Barkhan, D; Cox, JH; Zeira, M; Weinhold, KJ; Reinsmoen, N; McCutchan, F ...

Published in: Hum Immunol

June 2004

Published version (DOI) Link to item

A cohort of 35 human immunodeficiency virus type 1 (HIV-1) subtype C-infected Ethiopians was studied to define the HLA phenotype in all 35 subjects and highly conserved Gag protein regions involved in cross-clade cell-mediated immunity. Full-length Gag virus sequences were determined in 15 individuals. CD8 cell-mediated immune responses were detected by interferon-gamma ELISpot assay. HLA-A*03, -B*49, and -B*57 allelic frequencies were relatively higher than in other African populations. Anti-p17 (aa 1-60) CD8+ were detectable in the highest number of individuals. Anti-p17 (aa 1-60 and 51-110) cross-clade responses against subtype B and C were detected in 50% of the tested subjects. The p24 KF11 (aa 162-172) epitope was found to be immunodominant among the HLA-B*5703--positive individuals. These data represent the first report of correlating HLA phenotype and HIV-specific cell-mediated immune responses among infected Ethiopians and may be useful in designing cytotoxic T lymphocyte-inducing vaccines for this part of Africa.

Duke Scholars

Author Guido Ferrari Surgery, Surgical Sciences

Author Kent James Weinhold Surgery, Surgical Sciences

Published In

Hum Immunol

DOI

10.1016/j.humimm.2004.02.031

ISSN

0198-8859

Publication Date

June 2004

Volume

Issue

Start / End Page

648 / 659

Location

United States

Related Subject Headings

T-Lymphocytes, Cytotoxic
Phenotype
Male
Interferon-gamma
Immunology
Immunity, Cellular
Humans
HLA-B Antigens
HLA-A Antigens
HIV-1

Citation

APA

Chicago

ICMJE

MLA

NLM

Ferrari, G., Currier, J. R., Harris, M. E., Finkelstein, S., de Oliveira, A., Barkhan, D., … Maayan, S. (2004). HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians. Hum Immunol, 65(6), 648–659. https://doi.org/10.1016/j.humimm.2004.02.031

Ferrari, Guido, Jeffrey R. Currier, Matthew E. Harris, Stella Finkelstein, Angelica de Oliveira, Debra Barkhan, Josephine H. Cox, et al. “HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians.” Hum Immunol 65, no. 6 (June 2004): 648–59. https://doi.org/10.1016/j.humimm.2004.02.031.

Ferrari G, Currier JR, Harris ME, Finkelstein S, de Oliveira A, Barkhan D, et al. HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians. Hum Immunol. 2004 Jun;65(6):648–59.

Ferrari, Guido, et al. “HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians.” Hum Immunol, vol. 65, no. 6, June 2004, pp. 648–59. Pubmed, doi:10.1016/j.humimm.2004.02.031.

Ferrari G, Currier JR, Harris ME, Finkelstein S, de Oliveira A, Barkhan D, Cox JH, Zeira M, Weinhold KJ, Reinsmoen N, McCutchan F, Birx DL, Osmanov S, Maayan S. HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians. Hum Immunol. 2004 Jun;65(6):648–659.

Published In

Hum Immunol

DOI

10.1016/j.humimm.2004.02.031

ISSN

0198-8859

Publication Date

June 2004

Volume

Issue

Start / End Page

648 / 659

Location

United States

Related Subject Headings

T-Lymphocytes, Cytotoxic
Phenotype
Male
Interferon-gamma
Immunology
Immunity, Cellular
Humans
HLA-B Antigens
HLA-A Antigens
HIV-1