Tight linkage of apolipoprotein C2 to myotonic dystrophy on chromosome 19.
Publication
, Journal Article
Pericak-Vance, MA; Yamaoka, LH; Assinder, RI; Hung, WY; Bartlett, RJ; Stajich, JM; Gaskell, PC; Ross, DA; Sherman, S; Fey, GH
Published in: Neurology
November 1986
The cDNA and genomic probes for apolipoprotein C2 detect two restriction fragment length polymorphisms on chromosome 19. The combined estimated percentage of heterozygosity, assuming equilibrium, is approximately 75%, ie, apolipoprotein C2 is informative in 75% of matings. We have analyzed over 350 individuals in large multigenerational families for linkage of apolipoprotein C2 to myotonic muscular dystrophy. The maximum lod score was 16.29 with the maximum recombination fraction (theta) of 0.02, with 95% confidence limits for theta of 0.001 to 0.065. Thus, apolipoprotein C2 is useful in carrier detection and prenatal diagnosis with an accuracy of about 98%.
Duke Scholars
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
November 1986
Volume
36
Issue
11
Start / End Page
1418 / 1423
Location
United States
Related Subject Headings
- Polymorphism, Genetic
- Neurology & Neurosurgery
- Myotonic Dystrophy
- Male
- Humans
- Genetic Linkage
- Female
- Chromosomes, Human, 19-20
- Apolipoproteins
- 3209 Neurosciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Pericak-Vance, M. A., Yamaoka, L. H., Assinder, R. I., Hung, W. Y., Bartlett, R. J., Stajich, J. M., … Fey, G. H. (1986). Tight linkage of apolipoprotein C2 to myotonic dystrophy on chromosome 19. Neurology, 36(11), 1418–1423. https://doi.org/10.1212/wnl.36.11.1418
Pericak-Vance, M. A., L. H. Yamaoka, R. I. Assinder, W. Y. Hung, R. J. Bartlett, J. M. Stajich, P. C. Gaskell, D. A. Ross, S. Sherman, and G. H. Fey. “Tight linkage of apolipoprotein C2 to myotonic dystrophy on chromosome 19.” Neurology 36, no. 11 (November 1986): 1418–23. https://doi.org/10.1212/wnl.36.11.1418.
Pericak-Vance MA, Yamaoka LH, Assinder RI, Hung WY, Bartlett RJ, Stajich JM, et al. Tight linkage of apolipoprotein C2 to myotonic dystrophy on chromosome 19. Neurology. 1986 Nov;36(11):1418–23.
Pericak-Vance, M. A., et al. “Tight linkage of apolipoprotein C2 to myotonic dystrophy on chromosome 19.” Neurology, vol. 36, no. 11, Nov. 1986, pp. 1418–23. Pubmed, doi:10.1212/wnl.36.11.1418.
Pericak-Vance MA, Yamaoka LH, Assinder RI, Hung WY, Bartlett RJ, Stajich JM, Gaskell PC, Ross DA, Sherman S, Fey GH. Tight linkage of apolipoprotein C2 to myotonic dystrophy on chromosome 19. Neurology. 1986 Nov;36(11):1418–1423.
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
November 1986
Volume
36
Issue
11
Start / End Page
1418 / 1423
Location
United States
Related Subject Headings
- Polymorphism, Genetic
- Neurology & Neurosurgery
- Myotonic Dystrophy
- Male
- Humans
- Genetic Linkage
- Female
- Chromosomes, Human, 19-20
- Apolipoproteins
- 3209 Neurosciences