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Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study.

Publication ,  Journal Article
Pericak-Vance, MA; Rimmler, JB; Haines, JL; Garcia, ME; Oksenberg, JR; Barcellos, LF; Lincoln, R; Hauser, SL; Cournu-Rebeix, I; Azoulay-Cayla, A ...
Published in: Neurogenetics
February 2004

Multiple sclerosis (MS) is a demyelinating autoimmune disease with a strong yet complex genetic component. To date only the HLA-DR locus, and specifically the HLA-DR15 allele, has been identified and confirmed as influencing the risk of developing MS. Genomic screens on several datasets have been performed and have identified several chromosomal regions with interesting results, but none have yet been confirmed. We tested seven of the most-promising regions (on chromosomes 1p, 2p, 3p, 3q, 5q, 19q, and Xp) identified from several genomic screens in a dataset of 98 multiplex MS families from the United States and 90 multiplex MS families from France. The results did not confirm linkage to 2p, 3q, 5q, or Xp in the overall dataset, or in subsets defined by geographic origin or HLA-DR15 status. Regions on 1p34, 3p14, and 19q13 produced lod scores >0.90 in at least one subset of the data, suggesting that these regions should be examined in more detail.

Duke Scholars

Published In

Neurogenetics

DOI

ISSN

1364-6745

Publication Date

February 2004

Volume

5

Issue

1

Start / End Page

45 / 48

Location

United States

Related Subject Headings

  • United States
  • Neurology & Neurosurgery
  • Multiple Sclerosis
  • Humans
  • HLA-DR Serological Subtypes
  • HLA-DR Antigens
  • Genetic Predisposition to Disease
  • Genetic Linkage
  • France
  • Cooperative Behavior
 

Citation

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MLA
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Pericak-Vance, M. A., Rimmler, J. B., Haines, J. L., Garcia, M. E., Oksenberg, J. R., Barcellos, L. F., … Clerget-Darpoux, F. (2004). Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study. Neurogenetics, 5(1), 45–48. https://doi.org/10.1007/s10048-003-0163-y
Pericak-Vance, Margaret A., Jackie B. Rimmler, Jonathan L. Haines, Melissa E. Garcia, Jorge R. Oksenberg, Lisa F. Barcellos, Robin Lincoln, et al. “Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study.Neurogenetics 5, no. 1 (February 2004): 45–48. https://doi.org/10.1007/s10048-003-0163-y.
Pericak-Vance MA, Rimmler JB, Haines JL, Garcia ME, Oksenberg JR, Barcellos LF, et al. Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study. Neurogenetics. 2004 Feb;5(1):45–8.
Pericak-Vance, Margaret A., et al. “Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study.Neurogenetics, vol. 5, no. 1, Feb. 2004, pp. 45–48. Pubmed, doi:10.1007/s10048-003-0163-y.
Pericak-Vance MA, Rimmler JB, Haines JL, Garcia ME, Oksenberg JR, Barcellos LF, Lincoln R, Hauser SL, Cournu-Rebeix I, Azoulay-Cayla A, Lyon-Caen O, Fontaine B, Duhamel E, Coppin H, Brassat D, Roth M-P, Clanet M, Alizadeh M, Yaouanq J, Quelvennec E, Semana G, Edan G, Babron M-C, Genin E, Clerget-Darpoux F. Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study. Neurogenetics. 2004 Feb;5(1):45–48.
Journal cover image

Published In

Neurogenetics

DOI

ISSN

1364-6745

Publication Date

February 2004

Volume

5

Issue

1

Start / End Page

45 / 48

Location

United States

Related Subject Headings

  • United States
  • Neurology & Neurosurgery
  • Multiple Sclerosis
  • Humans
  • HLA-DR Serological Subtypes
  • HLA-DR Antigens
  • Genetic Predisposition to Disease
  • Genetic Linkage
  • France
  • Cooperative Behavior