Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19.
Publication
, Journal Article
Yamaoka, LH; Pericak-Vance, MA; Speer, MC; Gaskell, PC; Stajich, J; Haynes, C; Hung, WY; Laberge, C; Thibault, MC; Mathieu, J
Published in: Neurology
February 1990
The myotonic dystrophy (DM) gene is localized to the proximal long arm of chromosome 19. There have been reports of tight linkage to a number of chromosome 19 markers, including APOC2 and creatine kinase muscle type (CKMM), but they did not establish orientation of the 2 markers to DM. We screened several large multi-generational DM families for linkage to a series of chromosome 19 markers including CKMM. CKMM is tightly linked to DM in these data with z(theta) = 28.41; theta = 0.01. Analysis of cross-over data indicates CKMM is on the same side and closer to DM than APOC2. Thus, CKMM is a useful probe for carrier detection studies in presymptomatic individuals as well as for prenatal diagnosis.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
February 1990
Volume
40
Issue
2
Start / End Page
222 / 226
Location
United States
Related Subject Headings
- Pedigree
- Neurology & Neurosurgery
- Myotonic Dystrophy
- Muscles
- Male
- Lod Score
- Humans
- Genetic Linkage
- Female
- Crossing Over, Genetic
Citation
APA
Chicago
ICMJE
MLA
NLM
Yamaoka, L. H., Pericak-Vance, M. A., Speer, M. C., Gaskell, P. C., Stajich, J., Haynes, C., … Mathieu, J. (1990). Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19. Neurology, 40(2), 222–226. https://doi.org/10.1212/wnl.40.2.222
Yamaoka, L. H., M. A. Pericak-Vance, M. C. Speer, P. C. Gaskell, J. Stajich, C. Haynes, W. Y. Hung, C. Laberge, M. C. Thibault, and J. Mathieu. “Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19.” Neurology 40, no. 2 (February 1990): 222–26. https://doi.org/10.1212/wnl.40.2.222.
Yamaoka LH, Pericak-Vance MA, Speer MC, Gaskell PC, Stajich J, Haynes C, et al. Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19. Neurology. 1990 Feb;40(2):222–6.
Yamaoka, L. H., et al. “Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19.” Neurology, vol. 40, no. 2, Feb. 1990, pp. 222–26. Pubmed, doi:10.1212/wnl.40.2.222.
Yamaoka LH, Pericak-Vance MA, Speer MC, Gaskell PC, Stajich J, Haynes C, Hung WY, Laberge C, Thibault MC, Mathieu J. Tight linkage of creatine kinase (CKMM) to myotonic dystrophy on chromosome 19. Neurology. 1990 Feb;40(2):222–226.
Published In
Neurology
DOI
ISSN
0028-3878
Publication Date
February 1990
Volume
40
Issue
2
Start / End Page
222 / 226
Location
United States
Related Subject Headings
- Pedigree
- Neurology & Neurosurgery
- Myotonic Dystrophy
- Muscles
- Male
- Lod Score
- Humans
- Genetic Linkage
- Female
- Crossing Over, Genetic