Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35.
Publication
, Journal Article
Hentati, A; Bejaoui, K; Pericak-Vance, MA; Hentati, F; Speer, MC; Hung, WY; Figlewicz, DA; Haines, J; Rimmler, J; Ben Hamida, C
Published in: Nat Genet
July 1994
Amyotrophic lateral sclerosis (ALS) usually presents as a sporadic disorder of motor neurons. However, familial forms of ALS have been described--autosomal dominant forms (ALS1, ALS3), clinically indistinguishable from the sporadic form, and autosomal recessive forms with early onset and slower progression of symptoms (ALS2). To localize the gene for one of the autosomal recessive forms of ALS, we applied linkage analysis to a large inbred family from Tunisia. A lod score maximum of Zmax = 8.2 at theta = 0.00 was obtained with marker D2S72 located on chromosome 2q33-q35. The fine mapping of this region suggested that the ALS2 locus lies in the 8 cM segment flanked by D2S155 and D2S115.
Duke Scholars
Published In
Nat Genet
DOI
ISSN
1061-4036
Publication Date
July 1994
Volume
7
Issue
3
Start / End Page
425 / 428
Location
United States
Related Subject Headings
- Tunisia
- Repetitive Sequences, Nucleic Acid
- Polymorphism, Restriction Fragment Length
- Polymorphism, Genetic
- Pedigree
- Male
- Lod Score
- Humans
- Haplotypes
- Genetic Markers
Citation
APA
Chicago
ICMJE
MLA
NLM
Hentati, A., Bejaoui, K., Pericak-Vance, M. A., Hentati, F., Speer, M. C., Hung, W. Y., … Ben Hamida, C. (1994). Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35. Nat Genet, 7(3), 425–428. https://doi.org/10.1038/ng0794-425
Hentati, A., K. Bejaoui, M. A. Pericak-Vance, F. Hentati, M. C. Speer, W. Y. Hung, D. A. Figlewicz, J. Haines, J. Rimmler, and C. Ben Hamida. “Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35.” Nat Genet 7, no. 3 (July 1994): 425–28. https://doi.org/10.1038/ng0794-425.
Hentati A, Bejaoui K, Pericak-Vance MA, Hentati F, Speer MC, Hung WY, et al. Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35. Nat Genet. 1994 Jul;7(3):425–8.
Hentati, A., et al. “Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35.” Nat Genet, vol. 7, no. 3, July 1994, pp. 425–28. Pubmed, doi:10.1038/ng0794-425.
Hentati A, Bejaoui K, Pericak-Vance MA, Hentati F, Speer MC, Hung WY, Figlewicz DA, Haines J, Rimmler J, Ben Hamida C. Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33-q35. Nat Genet. 1994 Jul;7(3):425–428.
Published In
Nat Genet
DOI
ISSN
1061-4036
Publication Date
July 1994
Volume
7
Issue
3
Start / End Page
425 / 428
Location
United States
Related Subject Headings
- Tunisia
- Repetitive Sequences, Nucleic Acid
- Polymorphism, Restriction Fragment Length
- Polymorphism, Genetic
- Pedigree
- Male
- Lod Score
- Humans
- Haplotypes
- Genetic Markers