An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease.
Publication
, Journal Article
Sarfarazi, M; Upadhyaya, M; Padberg, G; Pericak-Vance, M; Siddique, T; Lucotte, G; Lunt, P
Published in: J Med Genet
August 1989
By using the genetic linkage data between the facioscapulohumeral muscular dystrophy (FSHD) gene and 57 markers on various autosomes, we have constructed an exclusion map for this disorder. The maximum likelihood location of the FSHD gene and the percentage of the excluded areas on each chromosome are presented here. This exclusion map shows that more than 80% of the genome has been excluded as a likely location of any locus responsible for FSHD in the majority of families. Chromosomes 3, 5, 10, 11, 15, and 19 remain largely unexcluded. Concentration on the highlighted areas of the genome should facilitate the identification of the site of the FSHD gene.
Duke Scholars
Published In
J Med Genet
DOI
ISSN
0022-2593
Publication Date
August 1989
Volume
26
Issue
8
Start / End Page
481 / 484
Location
England
Related Subject Headings
- Software
- Muscular Dystrophies
- Male
- Humans
- Genetics & Heredity
- Genetic Linkage
- Gene Frequency
- Female
- Data Interpretation, Statistical
- Chromosomes, Human, Pair 11
Citation
APA
Chicago
ICMJE
MLA
NLM
Sarfarazi, M., Upadhyaya, M., Padberg, G., Pericak-Vance, M., Siddique, T., Lucotte, G., & Lunt, P. (1989). An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease. J Med Genet, 26(8), 481–484. https://doi.org/10.1136/jmg.26.8.481
Sarfarazi, M., M. Upadhyaya, G. Padberg, M. Pericak-Vance, T. Siddique, G. Lucotte, and P. Lunt. “An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease.” J Med Genet 26, no. 8 (August 1989): 481–84. https://doi.org/10.1136/jmg.26.8.481.
Sarfarazi M, Upadhyaya M, Padberg G, Pericak-Vance M, Siddique T, Lucotte G, et al. An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease. J Med Genet. 1989 Aug;26(8):481–4.
Sarfarazi, M., et al. “An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease.” J Med Genet, vol. 26, no. 8, Aug. 1989, pp. 481–84. Pubmed, doi:10.1136/jmg.26.8.481.
Sarfarazi M, Upadhyaya M, Padberg G, Pericak-Vance M, Siddique T, Lucotte G, Lunt P. An exclusion map for facioscapulohumeral (Landouzy-Déjérine) disease. J Med Genet. 1989 Aug;26(8):481–484.
Published In
J Med Genet
DOI
ISSN
0022-2593
Publication Date
August 1989
Volume
26
Issue
8
Start / End Page
481 / 484
Location
England
Related Subject Headings
- Software
- Muscular Dystrophies
- Male
- Humans
- Genetics & Heredity
- Genetic Linkage
- Gene Frequency
- Female
- Data Interpretation, Statistical
- Chromosomes, Human, Pair 11