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Can restenosis after coronary angioplasty be predicted from clinical variables?

Publication ,  Journal Article
Weintraub, WS; Kosinski, AS; Brown, CL; King, SB
Published in: J Am Coll Cardiol
January 1993

OBJECTIVES: The purpose of this study was to determine whether variables shown to correlate with restenosis in one group (learning group) could be shown to predict recurrent stenosis in a second group (validation group). BACKGROUND: Restenosis remains a critical limitation after percutaneous transluminal coronary angioplasty. Although several clinical variables have been shown to correlate with restenosis, there are few data concerning attempts to predict recurrent stenosis. METHODS: The source of data was the clinical data base at Emory University. Patients who had had previous coronary surgery and patients who underwent coronary angioplasty in the setting of acute myocardial infarction were excluded. A total of 4,006 patients with angiographic restudy after successful angioplasty were identified. They were classified into a learning group of 2,500 patients and a validation group of 1,506 patients. The correlates of restenosis in the learning group were determined by stepwise logistic regression, and a model was developed to predict the probability of restenosis and was tested in the validation group. By using various cut points for the predicted probability of restenosis, a receiver operating characteristic curve was created. Goodness of fit of the model was evaluated by comparing average predicted probabilities with average observed probabilities within subgroups on the basis of risk level determined by linear regression analysis. RESULTS: In the learning group 1,145 patients had restenosis and 1,355 did not. Correlates of restenosis were severe angina, severe diameter stenosis before angioplasty, left anterior descending coronary artery dilation, diabetes, greater diameter stenosis after angioplasty, hypertension, absence of an intimal tear, eccentric morphology and older patient age. The model derived from the learning group was used to predict restenosis in the validation group. By varying the cut point for the predicted probability of restenosis above which restenosis is diagnosed and below which it is not, a receiver operating characteristic curve was created. The curve was close to the line of identity, reflecting a poor predictive ability. However, the model was shown to fit well with the predicted probability of restenosis correlating well with the observed probability (r = 0.98, p = 0.0001). CONCLUSIONS: Clinical variables provide limited ability to predict definitively whether a particular patient will have restenosis. However, the current model may be used to predict the probability of restenosis, with some uncertainty, at least in well characterized patients who have already had angioplasty.

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Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

January 1993

Volume

21

Issue

1

Start / End Page

6 / 14

Location

United States

Related Subject Headings

  • Risk Factors
  • Regression Analysis
  • Recurrence
  • ROC Curve
  • Prospective Studies
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • Georgia
 

Citation

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Weintraub, W. S., Kosinski, A. S., Brown, C. L., & King, S. B. (1993). Can restenosis after coronary angioplasty be predicted from clinical variables? J Am Coll Cardiol, 21(1), 6–14. https://doi.org/10.1016/0735-1097(93)90711-9
Weintraub, W. S., A. S. Kosinski, C. L. Brown, and S. B. King. “Can restenosis after coronary angioplasty be predicted from clinical variables?J Am Coll Cardiol 21, no. 1 (January 1993): 6–14. https://doi.org/10.1016/0735-1097(93)90711-9.
Weintraub WS, Kosinski AS, Brown CL, King SB. Can restenosis after coronary angioplasty be predicted from clinical variables? J Am Coll Cardiol. 1993 Jan;21(1):6–14.
Weintraub, W. S., et al. “Can restenosis after coronary angioplasty be predicted from clinical variables?J Am Coll Cardiol, vol. 21, no. 1, Jan. 1993, pp. 6–14. Pubmed, doi:10.1016/0735-1097(93)90711-9.
Weintraub WS, Kosinski AS, Brown CL, King SB. Can restenosis after coronary angioplasty be predicted from clinical variables? J Am Coll Cardiol. 1993 Jan;21(1):6–14.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

January 1993

Volume

21

Issue

1

Start / End Page

6 / 14

Location

United States

Related Subject Headings

  • Risk Factors
  • Regression Analysis
  • Recurrence
  • ROC Curve
  • Prospective Studies
  • Prognosis
  • Middle Aged
  • Male
  • Humans
  • Georgia