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Evaluating the exposure and disease relationship with adjustment for different types of exposure misclassification: a regression approach.

Publication ,  Journal Article
Kosinski, AS; Flanders, WD
Published in: Stat Med
October 30, 1999

Misclassification of exposure can lead to biased results in the epidemiologic research. Available methods accounting for misclassification often require the use of a gold standard or assume non-differential misclassification of exposure. We present a regression approach which can detect and account for different types of misclassification when estimating the exposure and disease relationship. This approach uses two imperfect measures of a dichotomous exposure and does not require a gold standard. Standard statistical packages with a logistic regression module can be used for estimation of parameters through the EM algorithm process. Two examples are used to illustrate the methodology.

Duke Scholars

Published In

Stat Med

DOI

ISSN

0277-6715

Publication Date

October 30, 1999

Volume

18

Issue

20

Start / End Page

2795 / 2808

Location

England

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Statistics & Probability
  • Regression Analysis
  • Randomized Controlled Trials as Topic
  • Male
  • Likelihood Functions
  • Humans
  • Female
  • Exercise Test
  • Coronary Disease
 

Citation

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Kosinski, A. S., & Flanders, W. D. (1999). Evaluating the exposure and disease relationship with adjustment for different types of exposure misclassification: a regression approach. Stat Med, 18(20), 2795–2808. https://doi.org/10.1002/(sici)1097-0258(19991030)18:20<2795::aid-sim192>3.0.co;2-s
Kosinski, A. S., and W. D. Flanders. “Evaluating the exposure and disease relationship with adjustment for different types of exposure misclassification: a regression approach.Stat Med 18, no. 20 (October 30, 1999): 2795–2808. https://doi.org/10.1002/(sici)1097-0258(19991030)18:20<2795::aid-sim192>3.0.co;2-s.
Kosinski, A. S., and W. D. Flanders. “Evaluating the exposure and disease relationship with adjustment for different types of exposure misclassification: a regression approach.Stat Med, vol. 18, no. 20, Oct. 1999, pp. 2795–808. Pubmed, doi:10.1002/(sici)1097-0258(19991030)18:20<2795::aid-sim192>3.0.co;2-s.
Journal cover image

Published In

Stat Med

DOI

ISSN

0277-6715

Publication Date

October 30, 1999

Volume

18

Issue

20

Start / End Page

2795 / 2808

Location

England

Related Subject Headings

  • Tomography, Emission-Computed, Single-Photon
  • Statistics & Probability
  • Regression Analysis
  • Randomized Controlled Trials as Topic
  • Male
  • Likelihood Functions
  • Humans
  • Female
  • Exercise Test
  • Coronary Disease