Skip to main content

Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis.

Publication ,  Journal Article
Ferguson, BJ; Mitchell, TG; Moon, R; Camporesi, EM; Farmer, J
Published in: Rev Infect Dis
1988

The therapy of rhinocerebral mucormycosis includes aggressive surgical debridement, administration of high-dose amphotericin B, and control of underlying predisposing conditions, especially diabetes and immunosuppression or immunodeficiency. Hyperbaric oxygen suppresses fungal growth in vitro and has theoretical value in treating mucormycosis because it reduces the tissue hypoxia and acidosis that accompany vascular invasion by the fungus. In a retrospective review of patients at Duke University Medical Center with rhinocerebral mucormycosis, six patients were treated with hyperbaric oxygen and seven cases (involving six patients) were treated without hyperbaric oxygen. All patients received surgical debridement and amphotericin B. Two of six patients receiving hyperbaric oxygen therapy died, and four of seven patients not receiving hyperbaric oxygen therapy died. Adverse effects from hyperbaric oxygen were minimal. Because mucormycosis occurs infrequently, this retrospective review involved a small number of patients. Despite this limitation, adjunctive hyperbaric oxygen appears to be a promising clinical modality for the treatment of rhinocerebral mucormycosis and warrants further investigation.

Duke Scholars

Published In

Rev Infect Dis

DOI

ISSN

0162-0886

Publication Date

1988

Volume

10

Issue

3

Start / End Page

551 / 559

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Nose Diseases
  • Mucormycosis
  • Middle Aged
  • Male
  • Hyperbaric Oxygenation
  • Humans
  • Female
  • Debridement
  • Combined Modality Therapy
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ferguson, B. J., Mitchell, T. G., Moon, R., Camporesi, E. M., & Farmer, J. (1988). Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis. Rev Infect Dis, 10(3), 551–559. https://doi.org/10.1093/clinids/10.3.551
Ferguson, B. J., T. G. Mitchell, R. Moon, E. M. Camporesi, and J. Farmer. “Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis.Rev Infect Dis 10, no. 3 (1988): 551–59. https://doi.org/10.1093/clinids/10.3.551.
Ferguson BJ, Mitchell TG, Moon R, Camporesi EM, Farmer J. Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis. Rev Infect Dis. 1988;10(3):551–9.
Ferguson, B. J., et al. “Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis.Rev Infect Dis, vol. 10, no. 3, 1988, pp. 551–59. Pubmed, doi:10.1093/clinids/10.3.551.
Ferguson BJ, Mitchell TG, Moon R, Camporesi EM, Farmer J. Adjunctive hyperbaric oxygen for treatment of rhinocerebral mucormycosis. Rev Infect Dis. 1988;10(3):551–559.

Published In

Rev Infect Dis

DOI

ISSN

0162-0886

Publication Date

1988

Volume

10

Issue

3

Start / End Page

551 / 559

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Nose Diseases
  • Mucormycosis
  • Middle Aged
  • Male
  • Hyperbaric Oxygenation
  • Humans
  • Female
  • Debridement
  • Combined Modality Therapy