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Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer.

Publication ,  Journal Article
Bovbjerg, DH; Redd, WH; Maier, LA; Holland, JC; Lesko, LM; Niedzwiecki, D; Rubin, SC; Hakes, TB
Published in: J Consult Clin Psychol
April 1990

Nausea and immune function were assessed in 20 cancer patients in the hospital prior to chemotherapy and compared with assessments conducted at home. Proliferative responses to T-cell mitogens were lower for cells isolated from hospital blood samples than for home samples obtained several days earlier. Patients also experienced increased nausea in the hospital. Hierarchical multiple regression analyses indicated that decreased immune function in the hospital was not related to increased anxiety. The observed anticipatory immune suppression is consistent with the hypothesis that chemotherapy patients may develop conditioned immune suppression as well as conditioned nausea after repeated pairings of hospital stimuli with the emetic and immunosuppressive effects of chemotherapy.

Duke Scholars

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Published In

J Consult Clin Psychol

DOI

ISSN

0022-006X

Publication Date

April 1990

Volume

58

Issue

2

Start / End Page

153 / 157

Location

United States

Related Subject Headings

  • Vomiting, Anticipatory
  • Ovarian Neoplasms
  • Middle Aged
  • Lymphocyte Activation
  • Leukocyte Count
  • Immune Tolerance
  • Humans
  • Female
  • Doxorubicin
  • Cyclophosphamide
 

Citation

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Bovbjerg, D. H., Redd, W. H., Maier, L. A., Holland, J. C., Lesko, L. M., Niedzwiecki, D., … Hakes, T. B. (1990). Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer. J Consult Clin Psychol, 58(2), 153–157. https://doi.org/10.1037//0022-006x.58.2.153
Bovbjerg, D. H., W. H. Redd, L. A. Maier, J. C. Holland, L. M. Lesko, D. Niedzwiecki, S. C. Rubin, and T. B. Hakes. “Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer.J Consult Clin Psychol 58, no. 2 (April 1990): 153–57. https://doi.org/10.1037//0022-006x.58.2.153.
Bovbjerg DH, Redd WH, Maier LA, Holland JC, Lesko LM, Niedzwiecki D, et al. Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer. J Consult Clin Psychol. 1990 Apr;58(2):153–7.
Bovbjerg, D. H., et al. “Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer.J Consult Clin Psychol, vol. 58, no. 2, Apr. 1990, pp. 153–57. Pubmed, doi:10.1037//0022-006x.58.2.153.
Bovbjerg DH, Redd WH, Maier LA, Holland JC, Lesko LM, Niedzwiecki D, Rubin SC, Hakes TB. Anticipatory immune suppression and nausea in women receiving cyclic chemotherapy for ovarian cancer. J Consult Clin Psychol. 1990 Apr;58(2):153–157.

Published In

J Consult Clin Psychol

DOI

ISSN

0022-006X

Publication Date

April 1990

Volume

58

Issue

2

Start / End Page

153 / 157

Location

United States

Related Subject Headings

  • Vomiting, Anticipatory
  • Ovarian Neoplasms
  • Middle Aged
  • Lymphocyte Activation
  • Leukocyte Count
  • Immune Tolerance
  • Humans
  • Female
  • Doxorubicin
  • Cyclophosphamide