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[Basis for a specific-active immunotherapy in malignant melanoma].

Publication ,  Journal Article
Mutzner, PA; Stuhlmiller, GM; Seigler, HF; Stumpf, WE; Sar, M
Published in: Schweiz Med Wochenschr
September 5, 1981

Since Morton demonstrated in 1968 that malignant melanoma is antigenic, many immunologists have taken an interest in this disease. A basis for specific active immunotherapy has been worked out at Duke University Medical Center, Durham, N.C. (USA). A female chimpanzee was hyperimmunized with melanoma cells grown in tissue culture. After appropriate absorptions the xeno-antiserum was tested by indirect immunofluorescence. Apart from unspecific activities in the serum detectable against normal human fetal and adult fibroblasts as well as other non-melanotic human tumors, following further absorptions with these cells a melanoma-specific antigen could be demonstrated on the surfaces of melanoma cells. The melanoma-specific tumor-associated antigens were further evaluated by direct and indirect immunoautoradiography. These studies suggest that there are indeed cross-reacting specific tumor-associated antigens on the cell surface of melanoma cells. At DUMC melanoma patients have therefore been hyperimmunized with melanoma cells + BCG. Clinical experience is discussed.

Duke Scholars

Published In

Schweiz Med Wochenschr

ISSN

0036-7672

Publication Date

September 5, 1981

Volume

111

Issue

36

Start / End Page

1322 / 1325

Location

Switzerland

Related Subject Headings

  • Pan troglodytes
  • Melanoma
  • Male
  • Immunotherapy
  • Immunization
  • Immune Sera
  • Humans
  • General & Internal Medicine
  • BCG Vaccine
  • Autoradiography
 

Citation

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ICMJE
MLA
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Mutzner, P. A., Stuhlmiller, G. M., Seigler, H. F., Stumpf, W. E., & Sar, M. (1981). [Basis for a specific-active immunotherapy in malignant melanoma]. Schweiz Med Wochenschr, 111(36), 1322–1325.
Mutzner, P. A., G. M. Stuhlmiller, H. F. Seigler, W. E. Stumpf, and M. Sar. “[Basis for a specific-active immunotherapy in malignant melanoma].Schweiz Med Wochenschr 111, no. 36 (September 5, 1981): 1322–25.
Mutzner PA, Stuhlmiller GM, Seigler HF, Stumpf WE, Sar M. [Basis for a specific-active immunotherapy in malignant melanoma]. Schweiz Med Wochenschr. 1981 Sep 5;111(36):1322–5.
Mutzner, P. A., et al. “[Basis for a specific-active immunotherapy in malignant melanoma].Schweiz Med Wochenschr, vol. 111, no. 36, Sept. 1981, pp. 1322–25.
Mutzner PA, Stuhlmiller GM, Seigler HF, Stumpf WE, Sar M. [Basis for a specific-active immunotherapy in malignant melanoma]. Schweiz Med Wochenschr. 1981 Sep 5;111(36):1322–1325.

Published In

Schweiz Med Wochenschr

ISSN

0036-7672

Publication Date

September 5, 1981

Volume

111

Issue

36

Start / End Page

1322 / 1325

Location

Switzerland

Related Subject Headings

  • Pan troglodytes
  • Melanoma
  • Male
  • Immunotherapy
  • Immunization
  • Immune Sera
  • Humans
  • General & Internal Medicine
  • BCG Vaccine
  • Autoradiography