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Anorectal melanoma: clinical characteristics and the role of abdominoperineal resection.

Publication ,  Journal Article
Slingluff, CL; Seigler, HF
Published in: Ann Plast Surg
January 1992

Twenty-four patients with primary anorectal melanoma diagnosed since 1974 have been retrospectively studied. The most common presenting symptom was rectal bleeding, typically misdiagnosed as hemorrhoids. Progressive disease most commonly presented as a large pelvic mass, diffuse bilateral pulmonary nodules, or diffuse liver metastases. Twenty-one patients (88%) died of their disease; none survived more than 6 years. Among the patients who have died of their disease, mean survival was 2.2 years. Among assessable stage I patients initially managed with abdominoperineal resection (APR), 50% developed recurrent local regional disease (mean disease-free interval = 23 months), compared with 100% of those managed with more limited surgery (mean disease-free interval = 16 months). Even after APR, however, distant metastases were common, and there was no prolongation of survival for patients treated with APR. Primary melanoma of the anorectum has a high metastatic potential and carries a grave prognosis. APR appears to have some effect in controlling local and regional disease, but prolongation of survival will depend both on earlier diagnosis and on development of more successful therapeutic approaches.

Duke Scholars

Published In

Ann Plast Surg

DOI

ISSN

0148-7043

Publication Date

January 1992

Volume

28

Issue

1

Start / End Page

85 / 88

Location

United States

Related Subject Headings

  • Survival Rate
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Rectal Neoplasms
  • Racial Groups
  • Prognosis
  • North Carolina
  • Neoplasm Staging
  • Neoplasm Recurrence, Local
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Slingluff, C. L., & Seigler, H. F. (1992). Anorectal melanoma: clinical characteristics and the role of abdominoperineal resection. Ann Plast Surg, 28(1), 85–88. https://doi.org/10.1097/00000637-199201000-00022
Slingluff, C. L., and H. F. Seigler. “Anorectal melanoma: clinical characteristics and the role of abdominoperineal resection.Ann Plast Surg 28, no. 1 (January 1992): 85–88. https://doi.org/10.1097/00000637-199201000-00022.
Slingluff CL, Seigler HF. Anorectal melanoma: clinical characteristics and the role of abdominoperineal resection. Ann Plast Surg. 1992 Jan;28(1):85–8.
Slingluff, C. L., and H. F. Seigler. “Anorectal melanoma: clinical characteristics and the role of abdominoperineal resection.Ann Plast Surg, vol. 28, no. 1, Jan. 1992, pp. 85–88. Pubmed, doi:10.1097/00000637-199201000-00022.
Slingluff CL, Seigler HF. Anorectal melanoma: clinical characteristics and the role of abdominoperineal resection. Ann Plast Surg. 1992 Jan;28(1):85–88.

Published In

Ann Plast Surg

DOI

ISSN

0148-7043

Publication Date

January 1992

Volume

28

Issue

1

Start / End Page

85 / 88

Location

United States

Related Subject Headings

  • Survival Rate
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Rectal Neoplasms
  • Racial Groups
  • Prognosis
  • North Carolina
  • Neoplasm Staging
  • Neoplasm Recurrence, Local