Functional and morphologic changes associated with insulinoma transplantation into diabetic rats.
Publication
, Journal Article
Reintgen, DS; Croker, B; Verveart, C; Seigler, HF
Published in: Am J Pathol
July 1983
Because of the technical difficulties encountered with human islet cell transplantation, alternatives toward supplying the juvenile diabetic with an endogenous insulin source are sought. With the use of a streptozotocin-induced diabetic rat model, it was found that by transplantation of a benign insulinoma, the glomerular deposition of material stained by the periodic acid-Schiff method, IgG, IgM, and C3 may be prevented. This effect was found only when transplantation of the insulin-producing tumor occurred within 2-4 weeks of the induction of diabetes. The data suggest that successful insulinoma engraftment can prevent the glomerular mesangial lesions from developing.
Duke Scholars
Published In
Am J Pathol
ISSN
0002-9440
Publication Date
July 1983
Volume
112
Issue
1
Start / End Page
1 / 6
Location
United States
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Pathology
- Pancreatic Neoplasms
- Pancreas
- Neoplasm Transplantation
- Microscopy, Electron
- Kidney
- Insulinoma
- Fluorescent Antibody Technique
Citation
APA
Chicago
ICMJE
MLA
NLM
Reintgen, D. S., Croker, B., Verveart, C., & Seigler, H. F. (1983). Functional and morphologic changes associated with insulinoma transplantation into diabetic rats. Am J Pathol, 112(1), 1–6.
Reintgen, D. S., B. Croker, C. Verveart, and H. F. Seigler. “Functional and morphologic changes associated with insulinoma transplantation into diabetic rats.” Am J Pathol 112, no. 1 (July 1983): 1–6.
Reintgen DS, Croker B, Verveart C, Seigler HF. Functional and morphologic changes associated with insulinoma transplantation into diabetic rats. Am J Pathol. 1983 Jul;112(1):1–6.
Reintgen, D. S., et al. “Functional and morphologic changes associated with insulinoma transplantation into diabetic rats.” Am J Pathol, vol. 112, no. 1, July 1983, pp. 1–6.
Reintgen DS, Croker B, Verveart C, Seigler HF. Functional and morphologic changes associated with insulinoma transplantation into diabetic rats. Am J Pathol. 1983 Jul;112(1):1–6.
Published In
Am J Pathol
ISSN
0002-9440
Publication Date
July 1983
Volume
112
Issue
1
Start / End Page
1 / 6
Location
United States
Related Subject Headings
- Rats, Inbred Strains
- Rats
- Pathology
- Pancreatic Neoplasms
- Pancreas
- Neoplasm Transplantation
- Microscopy, Electron
- Kidney
- Insulinoma
- Fluorescent Antibody Technique