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Effect of increased intracranial pressure on gastric acid secretion.

Publication ,  Journal Article
Mulvihill, SJ; Pappas, TN; Debas, HT
Published in: Am J Surg
January 1986

The effects of intracranial pressure on gastric acid secretion were studied in 30 rabbits. Intracranial pressure was increased in a graded and controlled fashion using a barostat connected to a cannula in the lateral cerebral ventricle. Eighteen rabbits were studied under urethane anesthesia with a background subthreshold intravenous infusion of bethanechol. Twelve rabbits were studied in the conscious state. Increases in intracranial pressure led to immediate and significant increases in gastric acid output in a dose-related manner in both conscious and anesthetized animals. Serum gastrin levels did not increase in either group of animals. Vagotomy only partially abolished the increase in acid outputs seen with increased intracranial pressure, whereas atropine completely blocked the response. We conclude that increased intracranial pressure causes stimulation of acid secretion by a gastrin-independent cholinergic mechanism that is only partially mediated by the vagus.

Duke Scholars

Published In

Am J Surg

DOI

ISSN

0002-9610

Publication Date

January 1986

Volume

151

Issue

1

Start / End Page

110 / 116

Location

United States

Related Subject Headings

  • Vagotomy
  • Urethane
  • Surgery
  • Stimulation, Chemical
  • Rabbits
  • Pentagastrin
  • Models, Biological
  • Intracranial Pressure
  • Humans
  • Gastrins
 

Citation

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ICMJE
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Mulvihill, S. J., Pappas, T. N., & Debas, H. T. (1986). Effect of increased intracranial pressure on gastric acid secretion. Am J Surg, 151(1), 110–116. https://doi.org/10.1016/0002-9610(86)90020-6
Mulvihill, S. J., T. N. Pappas, and H. T. Debas. “Effect of increased intracranial pressure on gastric acid secretion.Am J Surg 151, no. 1 (January 1986): 110–16. https://doi.org/10.1016/0002-9610(86)90020-6.
Mulvihill SJ, Pappas TN, Debas HT. Effect of increased intracranial pressure on gastric acid secretion. Am J Surg. 1986 Jan;151(1):110–6.
Mulvihill, S. J., et al. “Effect of increased intracranial pressure on gastric acid secretion.Am J Surg, vol. 151, no. 1, Jan. 1986, pp. 110–16. Pubmed, doi:10.1016/0002-9610(86)90020-6.
Mulvihill SJ, Pappas TN, Debas HT. Effect of increased intracranial pressure on gastric acid secretion. Am J Surg. 1986 Jan;151(1):110–116.
Journal cover image

Published In

Am J Surg

DOI

ISSN

0002-9610

Publication Date

January 1986

Volume

151

Issue

1

Start / End Page

110 / 116

Location

United States

Related Subject Headings

  • Vagotomy
  • Urethane
  • Surgery
  • Stimulation, Chemical
  • Rabbits
  • Pentagastrin
  • Models, Biological
  • Intracranial Pressure
  • Humans
  • Gastrins