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The use of somatostatin and its analogs in the treatment of surgical disorders.

Publication ,  Journal Article
Mulvihill, S; Pappas, TN; Passaro, E; Debas, HT
Published in: Surgery
September 1986

Somatostatin is a naturally occurring peptide with a wide spectrum of biologic actions, most of which are inhibitory in nature. It has wide distribution, and within the gastrointestinal tract is is found in the pancreas, the stomach, intestinal mucosa, and myenteric neurons. It appears to function as a classic circulating hormone, as well as both a paracrine or locally acting agent and a neurocrine agent. Because of its inhibitory actions on gut endocrine, secretory, and motor functions, it has potential applicability in the treatment of a variety of disorders of interest to the surgeon. Indeed, it has been used successfully in the management of upper gastrointestinal hemorrhage, secretory diarrhea, short bowel syndrome, pancreatitis, gastrointestinal fistulas, and peptide-secreting tumors of the gut (apudomas). This review discusses physiology, pathophysiology, and therapeutic applications of somatostatin that may be important in surgical practice.

Duke Scholars

Published In

Surgery

ISSN

0039-6060

Publication Date

September 1986

Volume

100

Issue

3

Start / End Page

467 / 476

Location

United States

Related Subject Headings

  • Surgery
  • Somatostatin
  • Short Bowel Syndrome
  • Paraneoplastic Endocrine Syndromes
  • Pancreatitis
  • Intestinal Obstruction
  • Intestinal Fistula
  • Humans
  • Gastrointestinal Hemorrhage
  • Gastrointestinal Diseases
 

Citation

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Mulvihill, S., Pappas, T. N., Passaro, E., & Debas, H. T. (1986). The use of somatostatin and its analogs in the treatment of surgical disorders. Surgery, 100(3), 467–476.
Mulvihill, S., T. N. Pappas, E. Passaro, and H. T. Debas. “The use of somatostatin and its analogs in the treatment of surgical disorders.Surgery 100, no. 3 (September 1986): 467–76.
Mulvihill S, Pappas TN, Passaro E, Debas HT. The use of somatostatin and its analogs in the treatment of surgical disorders. Surgery. 1986 Sep;100(3):467–76.
Mulvihill, S., et al. “The use of somatostatin and its analogs in the treatment of surgical disorders.Surgery, vol. 100, no. 3, Sept. 1986, pp. 467–76.
Mulvihill S, Pappas TN, Passaro E, Debas HT. The use of somatostatin and its analogs in the treatment of surgical disorders. Surgery. 1986 Sep;100(3):467–476.
Journal cover image

Published In

Surgery

ISSN

0039-6060

Publication Date

September 1986

Volume

100

Issue

3

Start / End Page

467 / 476

Location

United States

Related Subject Headings

  • Surgery
  • Somatostatin
  • Short Bowel Syndrome
  • Paraneoplastic Endocrine Syndromes
  • Pancreatitis
  • Intestinal Obstruction
  • Intestinal Fistula
  • Humans
  • Gastrointestinal Hemorrhage
  • Gastrointestinal Diseases