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Dextran sulfate sodium-induced colitis in immunodeficient rats.

Publication ,  Journal Article
Shichijo, K; Gottfried, M; Sekine, I; Pappas, TN
Published in: Dig Dis Sci
December 2000

To examine the morphology of colitis and study the role of the immune system in colitis, we compared colitis in immunocompetent Wistar-Kyoto rats with that in spontaneously hypertensive rats, known to have T-cell dysfunction. Rats were treated with 3% dextran sulfate in drinking water for periods ranging from 3 to 60 days. Diarrhea developed earlier and was associated with a more severe weight loss in Wistar-Kyoto rats than spontaneously hypertensive rats. The morphologic findings (flattening of the gland epithelium, gland dropout and ulceration) in spontaneously hypertensive rats were milder than in Wistar-Kyoto rats. Only spontaneously hypertensive rats survived 60 days of treatment; the findings included ulceration, crypt distortion, and inflammatory pseudopolyp formation. Immunostaining for B-cell, T-cell, and macrophage markers showed no difference in the distribution of these cells in the mucosa of Wistar-Kyoto rats and spontaneously hypertensive rats. Spontaneously hypertensive rats with T-cell dysfunction develop dextran sulfate sodium-induced colitis.

Duke Scholars

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

December 2000

Volume

45

Issue

12

Start / End Page

2320 / 2326

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Rats, Inbred WKY
  • Rats, Inbred SHR
  • Rats
  • Male
  • Intestinal Mucosa
  • Immunologic Deficiency Syndromes
  • Immunohistochemistry
  • Hypertension
  • Gastroenterology & Hepatology
 

Citation

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Shichijo, K., Gottfried, M., Sekine, I., & Pappas, T. N. (2000). Dextran sulfate sodium-induced colitis in immunodeficient rats. Dig Dis Sci, 45(12), 2320–2326. https://doi.org/10.1023/a:1005678606273
Shichijo, K., M. Gottfried, I. Sekine, and T. N. Pappas. “Dextran sulfate sodium-induced colitis in immunodeficient rats.Dig Dis Sci 45, no. 12 (December 2000): 2320–26. https://doi.org/10.1023/a:1005678606273.
Shichijo K, Gottfried M, Sekine I, Pappas TN. Dextran sulfate sodium-induced colitis in immunodeficient rats. Dig Dis Sci. 2000 Dec;45(12):2320–6.
Shichijo, K., et al. “Dextran sulfate sodium-induced colitis in immunodeficient rats.Dig Dis Sci, vol. 45, no. 12, Dec. 2000, pp. 2320–26. Pubmed, doi:10.1023/a:1005678606273.
Shichijo K, Gottfried M, Sekine I, Pappas TN. Dextran sulfate sodium-induced colitis in immunodeficient rats. Dig Dis Sci. 2000 Dec;45(12):2320–2326.
Journal cover image

Published In

Dig Dis Sci

DOI

ISSN

0163-2116

Publication Date

December 2000

Volume

45

Issue

12

Start / End Page

2320 / 2326

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Rats, Inbred WKY
  • Rats, Inbred SHR
  • Rats
  • Male
  • Intestinal Mucosa
  • Immunologic Deficiency Syndromes
  • Immunohistochemistry
  • Hypertension
  • Gastroenterology & Hepatology