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Role of vagus nerve in postprandial antropyloric coordination in conscious dogs.

Publication ,  Journal Article
Ueno, T; Uemura, K; Harris, MB; Pappas, TN; Takahashi, T
Published in: Am J Physiol Gastrointest Liver Physiol
March 2005

It is generally believed that gastric emptying of solids is regulated by a coordinated motor pattern between the antrum and pylorus. We studied the role of the vagus nerve in mediating postprandial coordination between the antrum and pylorus. Force transducers were implanted on the serosal surface of the body, antrum, pylorus, and duodenum in seven dogs. Dogs were given either a solid or a liquid meal, and gastroduodenal motility was recorded over 10 h. Gastric emptying was evaluated with radiopaque markers mixed with a solid meal. Dogs were treated with hexamethonium, N(G)-nitro-l-arginine methyl ester (l-NAME), or transient vagal nerve blockade by cooling. A postprandial motility pattern showed three distinct phases: early, intermediate, and late. In the late phase, profound pyloric relaxations predominantly synchronized with giant antral contractions that were defined as postprandial antropyloric coordination. A gastric emptying study revealed that the time at which gastric contents entered into the duodenum occurred concomitantly with antropyloric coordination. Treatment by vagal blockade or hexamethonium significantly reduced postprandial antral contractions and pyloric relaxations of the late phase. l-NAME changed pyloric motor patterns from relaxation dominant to contraction dominant. Solid gastric emptying was significantly attenuated by treatment with hexamethonium, l-NAME, and vagal blockade. Postprandial antropyloric coordination was not seen after feeding a liquid meal. It is concluded that postprandial antropyloric coordination plays an important role to regulate gastric emptying of a solid food. Postprandial antropyloric coordination is regulated by the vagus nerve and nitrergic neurons in conscious dogs.

Duke Scholars

Published In

Am J Physiol Gastrointest Liver Physiol

DOI

ISSN

0193-1857

Publication Date

March 2005

Volume

288

Issue

3

Start / End Page

G487 / G495

Location

United States

Related Subject Headings

  • Vagus Nerve
  • Stomach
  • Pylorus
  • Pyloric Antrum
  • Postprandial Period
  • Nitric Oxide Synthase
  • Nicotinic Antagonists
  • NG-Nitroarginine Methyl Ester
  • Male
  • Hexamethonium
 

Citation

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Ueno, T., Uemura, K., Harris, M. B., Pappas, T. N., & Takahashi, T. (2005). Role of vagus nerve in postprandial antropyloric coordination in conscious dogs. Am J Physiol Gastrointest Liver Physiol, 288(3), G487–G495. https://doi.org/10.1152/ajpgi.00195.2004
Ueno, Tomio, Kenichiro Uemura, Mary B. Harris, Theodore N. Pappas, and Toku Takahashi. “Role of vagus nerve in postprandial antropyloric coordination in conscious dogs.Am J Physiol Gastrointest Liver Physiol 288, no. 3 (March 2005): G487–95. https://doi.org/10.1152/ajpgi.00195.2004.
Ueno T, Uemura K, Harris MB, Pappas TN, Takahashi T. Role of vagus nerve in postprandial antropyloric coordination in conscious dogs. Am J Physiol Gastrointest Liver Physiol. 2005 Mar;288(3):G487–95.
Ueno, Tomio, et al. “Role of vagus nerve in postprandial antropyloric coordination in conscious dogs.Am J Physiol Gastrointest Liver Physiol, vol. 288, no. 3, Mar. 2005, pp. G487–95. Pubmed, doi:10.1152/ajpgi.00195.2004.
Ueno T, Uemura K, Harris MB, Pappas TN, Takahashi T. Role of vagus nerve in postprandial antropyloric coordination in conscious dogs. Am J Physiol Gastrointest Liver Physiol. 2005 Mar;288(3):G487–G495.

Published In

Am J Physiol Gastrointest Liver Physiol

DOI

ISSN

0193-1857

Publication Date

March 2005

Volume

288

Issue

3

Start / End Page

G487 / G495

Location

United States

Related Subject Headings

  • Vagus Nerve
  • Stomach
  • Pylorus
  • Pyloric Antrum
  • Postprandial Period
  • Nitric Oxide Synthase
  • Nicotinic Antagonists
  • NG-Nitroarginine Methyl Ester
  • Male
  • Hexamethonium