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Mechanical correlates of the third heart sound.

Publication ,  Journal Article
Glower, DD; Murrah, RL; Olsen, CO; Davis, JW; Rankin, JS
Published in: J Am Coll Cardiol
February 1992

In seven chronically instrumented conscious dogs, micromanometers measured left ventricular pressure, and ultrasonic dimension transducers measured left ventricular minor-axis diameter; the latter recording was filtered to examine data between 20 and 100 Hz. Acceptable external heart sounds were recorded with a phonocardiographic microphone in four of the seven dogs. With each dog sedated, intubated and mechanically ventilated, data were obtained during hemodynamic alterations produced by volume loading, phenylephrine, calcium infusion and vena caval occlusion. Damped oscillations were noted consistently in the left ventricular diameter waveform toward the end of rapid ventricular filling. These wall vibrations, assessed by the filtered diameter, correlated well with the third heart sound (S3) on the phonocardiogram. The peak frequency of the wall vibrations increased with increased diastolic pressure (p = 0.004), probably reflecting an increase in myocardial wall stiffness. In contrast, the amplitude of the vibrations varied directly with left ventricular filling rate (p = 0.0001). Thus, S3 seemed to be related specifically to ventricular wall vibrations during rapid filling, and the spectra of the amplitude-frequency relation shifted toward the audible range with increases in diastolic pressure, wall stiffness or filling rate. Spectral analysis of S3 may be useful in assessing pathologic changes in myocardial wall properties.

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Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

February 1992

Volume

19

Issue

2

Start / End Page

450 / 457

Location

United States

Related Subject Headings

  • Ventricular Function
  • Phonocardiography
  • Myocardial Contraction
  • Manometry
  • Heart Sounds
  • Fourier Analysis
  • Dogs
  • Cardiovascular System & Hematology
  • Animals
  • 3201 Cardiovascular medicine and haematology
 

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Glower, D. D., Murrah, R. L., Olsen, C. O., Davis, J. W., & Rankin, J. S. (1992). Mechanical correlates of the third heart sound. J Am Coll Cardiol, 19(2), 450–457. https://doi.org/10.1016/0735-1097(92)90504-g
Glower, D. D., R. L. Murrah, C. O. Olsen, J. W. Davis, and J. S. Rankin. “Mechanical correlates of the third heart sound.J Am Coll Cardiol 19, no. 2 (February 1992): 450–57. https://doi.org/10.1016/0735-1097(92)90504-g.
Glower DD, Murrah RL, Olsen CO, Davis JW, Rankin JS. Mechanical correlates of the third heart sound. J Am Coll Cardiol. 1992 Feb;19(2):450–7.
Glower, D. D., et al. “Mechanical correlates of the third heart sound.J Am Coll Cardiol, vol. 19, no. 2, Feb. 1992, pp. 450–57. Pubmed, doi:10.1016/0735-1097(92)90504-g.
Glower DD, Murrah RL, Olsen CO, Davis JW, Rankin JS. Mechanical correlates of the third heart sound. J Am Coll Cardiol. 1992 Feb;19(2):450–457.
Journal cover image

Published In

J Am Coll Cardiol

DOI

ISSN

0735-1097

Publication Date

February 1992

Volume

19

Issue

2

Start / End Page

450 / 457

Location

United States

Related Subject Headings

  • Ventricular Function
  • Phonocardiography
  • Myocardial Contraction
  • Manometry
  • Heart Sounds
  • Fourier Analysis
  • Dogs
  • Cardiovascular System & Hematology
  • Animals
  • 3201 Cardiovascular medicine and haematology