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Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas.

Publication ,  Journal Article
Cho, HJ; Seiberg, M; Georgoff, I; Teresky, AK; Marks, JR; Levine, AJ
Published in: J Neurosci Res
September 1989

Transgenic mice harboring the SV40 large T antigen gene in a C57B1/6J genetic background (SV11) first express this gene at 1-2 weeks of age, develop papillomas of the choroid plexus by 80-90 days, and die within 125 days after birth. Transgenic mice harboring the same transgene in a (SV11-C57Bl/6J x NZW/lacJ) F1 genetic background express considerably lower levels of the transgene mRNA at comparable times after birth. As a consequence, tumor development and death are delayed. The NZW mice appear to contribute a dominant negative regulator for the expression of the SV40 large T antigen transgene, which in turn has a dramatic effect upon the time of appearance of tumors and the death of these transgenic animals.

Duke Scholars

Published In

J Neurosci Res

DOI

ISSN

0360-4012

Publication Date

September 1989

Volume

24

Issue

1

Start / End Page

115 / 122

Location

United States

Related Subject Headings

  • Time Factors
  • Simian virus 40
  • RNA, Viral
  • RNA Probes
  • RNA
  • Phenotype
  • Papilloma
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cho, H. J., Seiberg, M., Georgoff, I., Teresky, A. K., Marks, J. R., & Levine, A. J. (1989). Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas. J Neurosci Res, 24(1), 115–122. https://doi.org/10.1002/jnr.490240116
Cho, H. J., M. Seiberg, I. Georgoff, A. K. Teresky, J. R. Marks, and A. J. Levine. “Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas.J Neurosci Res 24, no. 1 (September 1989): 115–22. https://doi.org/10.1002/jnr.490240116.
Cho HJ, Seiberg M, Georgoff I, Teresky AK, Marks JR, Levine AJ. Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas. J Neurosci Res. 1989 Sep;24(1):115–22.
Cho, H. J., et al. “Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas.J Neurosci Res, vol. 24, no. 1, Sept. 1989, pp. 115–22. Pubmed, doi:10.1002/jnr.490240116.
Cho HJ, Seiberg M, Georgoff I, Teresky AK, Marks JR, Levine AJ. Impact of the genetic background of transgenic mice upon the formation and timing of choroid plexus papillomas. J Neurosci Res. 1989 Sep;24(1):115–122.
Journal cover image

Published In

J Neurosci Res

DOI

ISSN

0360-4012

Publication Date

September 1989

Volume

24

Issue

1

Start / End Page

115 / 122

Location

United States

Related Subject Headings

  • Time Factors
  • Simian virus 40
  • RNA, Viral
  • RNA Probes
  • RNA
  • Phenotype
  • Papilloma
  • Neurology & Neurosurgery
  • Mice, Transgenic
  • Mice